About this Course
Please note: This course was developed in 2014. This course is not actively moderated by course instructors, please use the course forums to collaborate with other learners. Knowledge linking genomics to health and disease is rapidly expanding. Translation of this knowledge into clinical and public health practice offers promising opportunities but also raises a host of ethical, legal, social, and policy questions. Using case examples, this inter-disciplinary course will explore the challenges of genomic and precision medicine. This seven week, inter-disciplinary course provides an introduction to ethical, legal, social, and policy issues that arise in the translation of genomic knowledge into medical and public health practice. It considers challenges in health related and reproductive testing/screening focusing on six specific areas: • Pre‐conception genetic diagnosis, and prenatal testing/screening • Newborn screening • Use of genomic sequencing technologies to diagnose and predict disease • Targeting genomic testing/screening by race/ethnicity • Direct‐to‐consumer genomic testing/screening • Use of “big data” for genomic research and genomic translation Course Objectives 1. Critique the promise of genomics and precision medicine for improving health outcomes for individuals and populations. 2. Through analysis of key cases, demonstrate an understanding of the ethical, legal, social, and policy (ELSI) challenges that accompany the translation of new genomic knowledge into clinical medicine and public health practice. 3. Apply a critical analysis of ELSI concerns to your professional practice (if relevant), your interest as a potential user of genomic knowledge, and as a citizen with a responsibility to shape health policy.
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100% online course

Start instantly and learn at your own schedule.
Clock

Approx. 9 hours to complete

Suggested: 6 hours/week
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English

Subtitles: English
Globe

100% online course

Start instantly and learn at your own schedule.
Clock

Approx. 9 hours to complete

Suggested: 6 hours/week
Comment Dots

English

Subtitles: English

Syllabus - What you will learn from this course

1

Section
Clock
1 hour to complete

Week 1

Introduction to Genetics in Medicine and Public Health, Genetics as a Tool in Cancer Prevention, and Genetic Screening....
Reading
4 videos (Total 46 min), 2 readings, 1 quiz
Video4 videos
Introduction: Genetics in Medicine and Public Health 13m
Cancer Genetics: Genetics as a Tool in Cancer Prevention 14m
Genetic Screening to Improve Health: Newborns and Beyond13m
Reading2 readings
Deflating the Genomic Bubble10m
PowerPoint Slides10m
Quiz1 practice exercises
Quiz: Week 120m

2

Section
Clock
2 hours to complete

Week 2

Reproductive Genetics...
Reading
3 videos (Total 56 min), 3 readings, 1 quiz
Video3 videos
Reproductive Genetics: Carrier Screening31m
Reproductive Genetics: Screening for Trisomy 21 19m
Reading3 readings
Reproductive Genetics10m
PowerPoint Slides10m
Self Assessment10m
Quiz1 practice exercises
Week 2 Quiz20m

3

Section
Clock
2 hours to complete

Week 3

Screening...
Reading
5 videos (Total 69 min), 2 readings, 1 quiz
Video5 videos
Screening: Newborn Screening Programs26m
Screening: Challenges in Achieving Benefit 13m
Screening: Screening Adults – Questions Coming our Way 11m
Cancer Genetics: "Incidental" Findings in Research and Clinical Care 14m
Reading2 readings
Screening10m
PowerPoint Slides10m
Quiz1 practice exercises
Week 3 Quiz12m

4

Section
Clock
1 hour to complete

Week 4

Genetic Technology in the Prediction and Diagnosis of Disease...
Reading
4 videos (Total 41 min), 3 readings, 1 quiz
Video4 videos
Growing Genetic Knowledge in the Early 20th Century11m
Dramatic Growth and Intersection of Genetics and Other Biomedical Sciences13m
What New Opportunities Will Precision Medicine Bring? 13m
Reading3 readings
Genetic Technology10m
PowerPoint Slides10m
Self Assessment10m
Quiz1 practice exercises
Week 4 Quiz14m

5

Section
Clock
2 hours to complete

Week 5

Race and Genetics...
Reading
3 videos (Total 56 min), 2 readings, 1 quiz
Video3 videos
History of Race and Racial Categories 21m
Race and Efforts to Eliminate Health Disparities 27m
Reading2 readings
Race and Genetics10m
PowerPoint slides10m
Quiz1 practice exercises
Week 5 Quiz20m

6

Section
Clock
2 hours to complete

Week 6

Direct to Consumer Testing...
Reading
3 videos (Total 55 min), 2 readings, 1 quiz
Video3 videos
Direct-to-Consumer Genomics: A Personal Journey 32m
Debate About Direct to Consumer Testing 17m
Reading2 readings
Direct to Consumer Testing10m
Self Assessment10m
Quiz1 practice exercises
Week 6 Quiz20m

7

Section
Clock
1 hour to complete

Week 7

Where Do We Go From Here?...
Reading
4 videos (Total 49 min), 2 readings, 1 quiz
Video4 videos
How Can Genomic Information Be Used for Benefit? 13m
The Problem of Limited Predictive Value 18m
Do We Need Big Data? 13m
Reading2 readings
Genomic Analysis Are the Future of Medicine10m
PowerPoint slides10m
Quiz1 practice exercises
Week 7 Quiz14m

Instructors

Avatar

Wylie Burke, MD, PhD

Professor, Department of Bioethics and Humanities, University of Washington
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Barbara A. Koenig, PhD

Professor of Medical Anthropology & Bioethics
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Julie N. Harris-Wai, Ph.D., MPH

Assistant Adjunct Professor

About University of California, San Francisco

The University of California, San Francisco, is dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and high-quality patient care. UC San Francisco is the only campus in the University of California system dedicated exclusively to the health sciences. UCSF's innovative, collaborative approaches for health care, research and education span disciplines across the health sciences and make it a world leader in scientific discovery and its translation into improved health....

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