Caffeine

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From the course by Emory University

The Addicted Brain

1113 ratings

Emory University

The Addicted Brain

1113 ratings

This is a course about addiction to drugs and other behaviors. It will describe what happens in the brain and how this information helps us deal with and overcome addiction. It will also discuss other topics such as government policy and our vulnerability to take drugs.

From the lesson

Classes of Drugs, Part 2 & Animal Models

Upon completion of this module, learners will be able to: Become familiar with the last three classes of abusable drugs: the inhalants, caffeine and others; review the 10 classes of abused and addicting drugs, their effects, and toxicities; recognize the importance of using animals in research on addicting drugs; compare two important animal models, self-administration and conditioned place preference (CPP); and recognize how both animal drug self-administration and conditioned place preference (CPP) are used to understand how drugs work in the brain and how they are used to screen for and develop new treatments and medications.

New and Other Substances4:41

Review of Ten Classes of Drugs6:12

Meet the Instructors

Michael Kuhar, Ph.D.
Professor
Yerkes/Emory Pharmacology and Neuroscience

Today we're going to talk about a substance that most

of us use every day, and that substance is caffeine.

Caffeine is well known to be a mild stimulant.

Many people take in the morning to get themselves going, as they say.

It's perhaps the most widely used psychoactive drug in the world.

Psychoactive means that it alters the way your mind functions.

It's found in a lot of plants, and there

is evidence that it produces abuse, tolerance and addiction.

Caffeine is found in coffee, tea, sodas,

chocolate, energy drinks, and many other things.

If you're used to taking caffeine all the time, and you haven't

had it for a day or so, you will probably experience some withdrawal.

At that time, the effects of caffeine could

be calming because your satisfying the withdrawal syndrome.

But if you're having caffeine frequently, and you're taking higher doses, you may

very well experience more severe effects due to the immediate effects of caffeine.

These include restlessness, nervousness, insomnia,

frequent urination, G.I. disturbance, muscle

twitching; a fast heart rate or a tachycardia, and other things.

After prolonged daily use of caffeine, and after stopping it abruptly,

or reducing its use significantly, the following may occur within 24 hours.

Headache, fatigue or drowsiness, a disphoric or unpleasant mood.

Depression, irritability, and you may have difficulty concentrating.

It is believed that the effects of caffeine

intake and the signs and symptoms of withdrawal

can cause significant distress or impairment in various

areas of your life, including social and occupational activities.

A survey revealed that 14% used caffeine despite harm,

and despite advice to stop or resto, or reduce it's use.

45%, reported failed efforts to control it's use.

Thus, caffeine has many of the properties of

other drugs that are abused and cause addiction.

You know that drugs of abuse are typically associated

with altering a specific neurotransmitter system in the brain.

What neurotransmitter does caffeine interact with?

Well, it's a neurotransmitter called adenosine.

Caffeine is an antagonist at two of several adenosine GPR receptors.

Ultimately, it increases dopamine activity in the brain as well.

Because caffeine is an antagonist or blocker of adenosine,

caffeine's actions are opposite to those of adenosine.

The neurotransmitter adenosine is involved in

inhibiting release of other neurotransmitters, reducing

excitation and convulsions, depressing locomotor activity,

and inhibiting the actions of the heart.

Just as we can treat our dependence

on other drugs, we can treat caffeine overuse.

A reasonable plan for caffeine addiction is as follows.

First, you should be made aware of the sources of caffeine.

Then you need to generate an awareness of caffeine intake by record keeping.

Once you're aware of how much caffeine you're taking in, then you can determine

a maximal intake goal, which could be zero, perhaps with a health professional.

Then you can gradually reduce the intake of caffeine til you reach your goal.

Throughout this, it can be helpful to participate in

counseling to help with and support this overall process.

While caffeine is only a mild stimulant, very available and

widely used, it nevertheless has been associated with health problems.

Patients have also found it difficult to stop, and they

exhibit many of the characteristics of being dependent and addicted.

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