This course has two main parts, one for the lower extremity and the other for the upper extremity. We will show how the various systems that supply and organize the limb control its function. There are a set of introductory lectures which will allow more experienced students to refresh their knowledge of the limbs and a guide to those with less experience. These lectures will be followed by detailed dissections of the extremities emphasizing locomotion for the lower extremities and hand positioning and function for the upper extremities. This course is part 2/4 in the Yale Human Anatomy Specialization.