In this module, Dr. Dix will give you the insight in the US EPA endocrine disruptor screening program, or short EDSP. You've probably heard about bisphenol A or BPA, a plasticizer which is broadly used in consumer products, such as plastic bottles, CDs, DVDs, and sport equipment. It was also used a lot in baby bottles and formula packages and toys, and was removed due to it's endocrine disruption activity. So what is an endocrine disruptor? It is a chemical which can act similar to hormones and interfere with your endocrine system, perturbing your hormone level. So BPA was removed from baby bottles and was replaced with BPS. Is BPS safer? Not even yet. How many other potential endocrine disruptors are around us in the products we are using everyday? How fast we can perform risk assessment of those compounds to declare them safe or remove them as quick as possible from the products? All these questions will be addressed in Dr. Dix's lesson. An estimate is that around 10,000 compounds should be screened for the endocrine disruption potency. In current animal-based battery of tests, 65 compounds were tested, which took over five years. So moving with this speed, we can protect our great grandchildren from exposure to endocrine disruptors, but certainly not us or our children. Dr. Dix demonstrate the potential of in vitro high throughput screening for endocrine disruptors testing, how to speed up the process. Also this lesson given by Dr. Kleinstreuer will explain two major high throughput screen programs run by US institutions, such as LCATS, NAHS, and EPA. She will give you some case examples of the developing of computational tests to study and predict development of toxicity.