Hierarchical Clustering using Euclidean Distance

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In this Guided Project, you will:

Understand the importance and usage of the hierarchical clustering using skew profiles.

Locate and process the viral cDNA genome files to calculate the skew profiles.

Understand the theory for using the Pythagorean equation to calculate the Euclidean distance. And apply that using python to build a linkage matrix.

Understand how errors occur, how to avoid them, and resolve their sources.

About 75 minutes required for the project and 45 for the other materials (reading and assignment).
No download needed
Split-screen video
Desktop only

By the end of this project, you will create a Python program using a jupyter interface that analyzes a group of viruses and plot a dendrogram based on similarities among them. The dendrogram that you will create will depend on the cumulative skew profile, which in turn depends on the nucleotide composition. You will use complete genome sequences for many viruses including, Corona, SARS, HIV, Zika, Dengue, enterovirus, and West Nile viruses.

Skills you will develop

  • Python Programming

  • Genomics

  • plotting

Learn step-by-step

In a video that plays in a split-screen with your work area, your instructor will walk you through these steps:

  1. Task 1: Getting Started with Hierarchical Clustering

  2. Task 2: Locate and Process The Data Files

  3. Task 3: Understand The Result Dataset

  4. Task 4: Hierarchical Clustering - Metric

  5. Task 5: Hierarchical Clustering - Ordering & Methods

  6. Task 6: Dendrogram Plotting

  7. Task 7: Dendrogram - Analysis

  8. Task 8: Errors to Avoid

How Guided Projects work

Your workspace is a cloud desktop right in your browser, no download required

In a split-screen video, your instructor guides you step-by-step

Frequently Asked Questions

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At the top of the page, you can press on the experience level for this Guided Project to view any knowledge prerequisites. For every level of Guided Project, your instructor will walk you through step-by-step.

Yes, everything you need to complete your Guided Project will be available in a cloud desktop that is available in your browser.

You'll learn by doing through completing tasks in a split-screen environment directly in your browser. On the left side of the screen, you'll complete the task in your workspace. On the right side of the screen, you'll watch an instructor walk you through the project, step-by-step.