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Learner Reviews & Feedback for Comparing Genes, Proteins, and Genomes (Bioinformatics III) by University of California San Diego
136 ratings
About the Course
Once we have sequenced genomes in the previous course, we would like to compare them to determine how species have evolved and what makes them different.
In the first half of the course, we will compare two short biological sequences, such as genes (i.e., short sequences of DNA) or proteins. We will encounter a powerful algorithmic tool called dynamic programming that will help us determine the number of mutations that have separated the two genes/proteins.
In the second half of the course, we will "zoom out" to compare entire genomes, where we see large scale mutations called genome rearrangements, seismic events that have heaved around large blocks of DNA over millions of years of evolution. Looking at the human and mouse genomes, we will ask ourselves: just as earthquakes are much more likely to occur along fault lines, are there locations in our genome that are "fragile" and more susceptible to be broken as part of genome rearrangements? We will see how combinatorial algorithms will help us answer this question.
Finally, you will learn how to apply popular bioinformatics software tools to solve problems in sequence alignment, including BLAST.
Top reviews
HN
Jun 21, 2017
I have taken courses I, II and III. They were consistently excellent. I plan to go for the next one.
RS
Nov 10, 2016
One of the most difficult courses so far, but working hard you made it.
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26 - 27 of 27 Reviews for Comparing Genes, Proteins, and Genomes (Bioinformatics III)
By Yudi,Tian
•May 19, 2019
I think I will need some pseudocode in stepik interactive material to complete the code challenge. some part still too confused to me
By Linbo Z
•Jul 10, 2017
I think Week 4 and 5 should be explained more. Pseudo-code can be more detailed.