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Learner Reviews & Feedback for Experimental Methods in Systems Biology by Icahn School of Medicine at Mount Sinai

243 ratings
39 reviews

About the Course

Learn about the technologies underlying experimentation used in systems biology, with particular focus on RNA sequencing, mass spec-based proteomics, flow/mass cytometry and live-cell imaging. A key driver of the systems biology field is the technology allowing us to delve deeper and wider into how cells respond to experimental perturbations. This in turns allows us to build more detailed quantitative models of cellular function, which can give important insight into applications ranging from biotechnology to human disease. This course gives a broad overview of a variety of current experimental techniques used in modern systems biology, with focus on obtaining the quantitative data needed for computational modeling purposes in downstream analyses. We dive deeply into four technologies in particular, mRNA sequencing, mass spectrometry-based proteomics, flow/mass cytometry, and live-cell imaging. These techniques are often used in systems biology and range from genome-wide coverage to single molecule coverage, millions of cells to single cells, and single time points to frequently sampled time courses. We present not only the theoretical background upon which these technologies work, but also enter real wet lab environments to provide instruction on how these techniques are performed in practice, and how resultant data are analyzed for quality and content....

Top reviews

Sep 21, 2019

Loved this course. Prof. Birtwistle is really into teaching and liked the way he has organized this course. Thanks!

Sep 29, 2020

Awesome delivery and exam questions are very practical....I enjoyed the 8weeks here

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26 - 40 of 40 Reviews for Experimental Methods in Systems Biology

By Nguyen P K

Aug 26, 2020

Very nice and thorough course. Information is explained clearly in lectures but some parts like data analysis may require a longer period to understand and process for people without sufficient background. Lab-based ones are helpful. Quizzes and exams are pretty challenging. I found the case studies in exams really practical and interesting!

By Pablo L

Nov 21, 2018

Really good course, even though the test were so unfair with the multiple choice questions. Why not to give any simple 0.2 or 0.25 if you get one answer out of 5? Why do I have to select all ofthem correctly if not I do not receive any point? Very unfair, 4 stars because of this. the rest of it is perfect even with lab based videos.

By Mohamad K K

Mar 4, 2016

very good introduction but as i go through the videos and then do the quiz i feel like the material doesn't highlight exactly what is needed for the quiz. Maybe i'm not taking the video lecture as seriously as i should. Something else to reinforce the material cause it seems a bit condensed.

thanks for a wonderful course!

By Erick C O

Feb 7, 2016

On the bright side, "Lab based" videos are excellent for visualize the techniques. Nevertheless "Choose all that apply" questions in the quizzes are very ambiguous, these questions should contain an explanation for prevent confusion at the end of every unit.

By Georgy I

Feb 21, 2016

Thanks for overview of experimental methods and references to relevant articles!

"Complete the essay" quizzes looks like a joke

By Samuel B

Mar 6, 2016

the lab was fasinating . i never seen those big machin in my life. THANKS!!!

By Chinaza N

Jun 5, 2020

The audio quality for the laboratory sessions was somewhat poor.


Mar 2, 2016

HighTech!! Quite difficult for someone who not from the field .

By Mohammad A M

Jul 17, 2020

I learned very cool and interesting things!

By Hazem H

Feb 7, 2016

it's interesting but it's quite difficult

By Seema P

Oct 2, 2018

Way to go..enjoyed learning

By Weidong X

Dec 3, 2016


By Pooja P

Aug 15, 2016

The course was very interesting. It touched upon all currently employed techniques in good detail. The lab-based videos were the most interesting. However, the lectures were too long. It would be a brilliant course if the lectures were cut short and made to the point.

By Rohaina T

Sep 29, 2016

The questions based on the lectures are quite different and confusing

By Alison P

Apr 16, 2018

quiz 5 from week 6 does not work.