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stars
74 ratings

Lena Smirnova +1 more instructor

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Toxicology 21: Scientific Applications

Johns Hopkins University

About this Course

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This course familiarizes students with the novel concepts being used to revamp regulatory toxicology in response to a breakthrough National Research Council Report “Toxicity Testing in the 21st Century: A Vision and a Strategy.” We present the latest developments in the field of toxicology—the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies. Active programs from EPA, NIH, and the global scientific community illustrate the dynamics of safety sciences.

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Shareable Certificate

Earn a Certificate upon completion

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Start instantly and learn at your own schedule.

Intermediate Level

Approx. 95 hours to complete

English

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Flexible deadlines

Reset deadlines in accordance to your schedule.

Shareable Certificate

Earn a Certificate upon completion

100% online

Start instantly and learn at your own schedule.

Intermediate Level

Approx. 95 hours to complete

English

Could your company benefit from training employees on in-demand skills?

Try Coursera for Business

Instructors

Instructor rating

4.68/5 (25 Ratings)

Lena Smirnova

Research Associate

Center for Alternatives to Animal Testing

14,730 Learners

2 Courses

Thomas Hartung

Professor

Environmental Health and Engineering

14,730 Learners

2 Courses

Offered by

Johns Hopkins University

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Syllabus - What you will learn from this course

Week1

Week 1

75 hours to complete

Module 1

75 hours to complete

10 videos (Total 121 min), 3 readings, 1 quiz

10 videos

Welcome to Module 14mCourse Introduction16mIntroduction49sCenter for Alternatives to Animal Testing4mToxicology of the Fifteenth to Twentieth Centuries15mToxicology for the Twenty-First Century15mHistorical Perspective17mThe First Report: Toxicity Testing for Assessment of Environmental Agents11mThe Second Report: Toxicity Testing in the 21st Century: A Vision and A Strategy Vision and Its Components22mThe Second Report: Toxicity Testing in the 21st Century: A vision and A Strategy Implementation13m

3 readings

useful links20msupporting reading material10mSupporting reading material10m

1 practice exercise

Module 1 Quizs

Week2

Week 2

4 hours to complete

Module 2

This module will discuss how ToxCast and Tox21 technologies can be used in practice. The US EPA Endocrine Disruptor Screening Program will be discussed in detail and we will demonstrate how the ToxCast platform replaced in vivo tiered approaches in EDSP and, thus, acelerate the process of . In the second lesson of this module, the development of in silico models for toxicity testing will be discussed.

4 hours to complete

10 videos (Total 119 min), 4 readings, 2 quizzes

10 videos

Welcome to Module 22mAdverse Outcome Pathways (AOPs)10mExposure-Based Chemical Prioritization13mER Bioactivity Model16mUS EPA Endocrine Disruptor Screening Program (EDSP)17mModeling of Hazard and Organ Manifestation11mBuilding a Signature for Vascular Disruption10mTesting the Vascular Disruption Signature8mVirtual Tissue Model: Vascular Development12mFunctional Vascular Development Assays16m

4 readings

Supporting Reading Material10mUseful links10mSupporting Reading Material10mUseful links10m

1 practice exercise

Module 2 Quiz30m

Week3

Week 3

3 hours to complete

Module 3

3 hours to complete

10 videos (Total 109 min), 2 readings, 1 quiz

10 videos

Welcome to Module 31mMechanistic Toxicology and Pathway Mapping at the Basics of 21st Century Toxicology16mThe Concept of the Human Toxome Project21mConcept and Tool Devlopment11mProgress7mConclusions and Prospectives8mIntroduction: What Is a Pathway of Toxicity, and Why Do We Need Them?5mOmics Technologies and High-Throughput Data6mInterpreting Omics Data11mUsing Network Approaches to Understand Toxicity Mechanisms18m

2 readings

Supporting reading materials10mSupporting reading material10m

1 practice exercise

Module 3 Quiz30m

Week4

Week 4

5 hours to complete

Module 4

The first lesson in this module will explain the concept of read-across, why it is important for regulatory risk assessment, and how it can be implemented by industry in response to REACH legislation. The organotypic cultures lesson will teach you about existing in vitro cell-based models starting from simple monolayer cultures of cell lines and ending with complex combined organ-on-a-chip and human-on-a-chip approaches.

5 hours to complete

18 videos (Total 185 min), 3 readings, 2 quizzes

18 videos

The Need, and Opportunity, for a New Approach to Toxicology, Including Predictive Tools7mThe Concept of Toxicological (Biological) Pathways, e.g., “Adverse Outcome Pathways,” Is the Basis of Predictive Toxicology5mIntroduction to the OECD AOP Framework10mBuilding, Evaluating, and Using AOPs in Safety Decisions6mOnline Tools Available to Everyone, Including an Online AOP Course4mWelcome to Module 42mIntroduction to Read-Across18mGood Read-Across Practice21mSupporting Read-Across with Biological Data12mCreating a Database of Toxicity12mCreating an Automated Tool for Read-Across9mCell Sources for In Vitro Models12mMonolayer Cultures4mAdvanced Cell Cultures: Microphysiological Systems (MPS)7m3D Cultures25mMicrofluidics2mOrgan-on-Chip, Body-on-Chip13mGood Cell Culture Practice7m

3 readings

Supporting reading material10mSupporting reading material10mUseful links10m

2 practice exercises

Module 4 Quiz30mMid-term exam30m

2 hours to complete

Module 5

2 hours to complete

6 videos (Total 41 min), 1 reading, 1 quiz

Week5

Week 5

4 hours to complete

Module 6

In this module you will learn about important component of in vitro toxicology such as in vitro to in vivo extrapolation (IVIVE) and physiologically based biokinetic modeling. You will learn why it is important to consider biokinetics in vitro and see some example of biokinetics modeling in vitro. This lesson will also give you a biometry prospective of in vitro toxicology. You will learn which methods can be used to analyze big data.

4 hours to complete

8 videos (Total 106 min), 3 readings, 2 quizzes

8 videos

Welcome to Module2mPhysiologically Based Biokinetic Modeling10mApplication of QIVIVE to in Vitro Testing14mChallenges for Conducting QIVIVE14mQuantitative in Vitro to in Vivo Extrapolation25mDefinition of Biometry/Biostatistics and Revisiting Some Statistical Basics17mTypes of Tox21 Data and Data Mining of External Data Sources8mBioinformatics Tools for the Interpretation of Tox21 Data13m

3 readings

Supporting reading material10mSupporting reading material10mUseful links10m

1 practice exercise

Module 6 Quiz30m

Week6

Week 6

4 hours to complete

Module 7

4 hours to complete

11 videos (Total 143 min), 2 readings, 2 quizzes

11 videos

Welcome to Module 73mWhy Integrated Testing Strategies?5mWhat is an Integrated Testing Strategy?16mHow to Compose Integrated Testing Strategies36mStrategies for Integrated Testing Strategies6mQuality Assurance of integrated Testing Strategies7mLegal Background13mEconomic Background23mTox-21c for Drug Safety12mGreen Toxicology as Non-regulatory Tox-21c Approaches12mConclusions and Prospects7m

2 readings

Supporting reading material10mSupporting reading material10m

2 practice exercises

Module 7 Quiz30mFinal Exam30m

Reviews

4.7

22 reviews

5 stars
79.72%
4 stars
12.16%
3 stars
5.40%
1 star
2.70%

TOP REVIEWS FROM TOXICOLOGY 21: SCIENTIFIC APPLICATIONS

by IMay 25, 2020

one of the best course helps students & researcher about what are challenges faced in toxicology in 21 century and finds the routes to develop new routes and methods for toxicology tests

by NKDec 26, 2018

A very well-taught course with lots of useful information. I highly recommend it.

by MMNov 29, 2020

Very nice and the teachers explanation are clear . It’s very interesting, specially if you work in the research-lab section

by SMay 3, 2018

Very nicely designed course. The instructors offer an excellent and easy to understand overview of a range of promising Tox21 tools and approaches using good examples and illustrations.

View all reviews

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Toxicology 21: Scientific Applications

Toxicology 21: Scientific Applications

About this Course