About this Course

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Intermediate Level
Approx. 96 hours to complete
English
Shareable Certificate
Earn a Certificate upon completion
100% online
Start instantly and learn at your own schedule.
Flexible deadlines
Reset deadlines in accordance to your schedule.
Intermediate Level
Approx. 96 hours to complete
English

Offered by

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Johns Hopkins University

Syllabus - What you will learn from this course

Week
1

Week 1

75 hours to complete

Module 1

75 hours to complete
10 videos (Total 121 min), 3 readings, 1 quiz
10 videos
Course Introduction16m
Introduction49s
Center for Alternatives to Animal Testing4m
Toxicology of the Fifteenth to Twentieth Centuries15m
Toxicology for the Twenty-First Century15m
Historical Perspective17m
The First Report: Toxicity Testing for Assessment of Environmental Agents11m
The Second Report: Toxicity Testing in the 21st Century: A Vision and A Strategy Vision and Its Components22m
The Second Report: Toxicity Testing in the 21st Century: A vision and A Strategy Implementation13m
3 readings
useful links20m
supporting reading material10m
Supporting reading material10m
1 practice exercise
Module 1 Quizs
Week
2

Week 2

4 hours to complete

Module 2

4 hours to complete
10 videos (Total 119 min), 4 readings, 2 quizzes
10 videos
Adverse Outcome Pathways (AOPs)10m
Exposure-Based Chemical Prioritization13m
ER Bioactivity Model16m
US EPA Endocrine Disruptor Screening Program (EDSP)17m
Modeling of Hazard and Organ Manifestation11m
Building a Signature for Vascular Disruption10m
Testing the Vascular Disruption Signature8m
Virtual Tissue Model: Vascular Development12m
Functional Vascular Development Assays16m
4 readings
Supporting Reading Material10m
Useful links10m
Supporting Reading Material10m
Useful links10m
1 practice exercise
Module 2 Quiz30m
Week
3

Week 3

3 hours to complete

Module 3

3 hours to complete
11 videos (Total 126 min), 2 readings, 1 quiz
11 videos
Mechanistic Toxicology and Pathway Mapping at the Basics of 21st Century Toxicology16m
The Concept of the Human Toxome Project21m
Concept and Tool Devlopment11m
Progress7m
Conclusions and Prospectives8m
Introduction - What Is a Pathway of Toxicity, and Why Do We Need Them?6m
Omics Technologies and High-Throughput Data11m
Interpreting Omics Data11m
PoT Examples and Conclusions15m
Pathways of Toxicity and Adverse Outcome Pathways (AOPs)13m
2 readings
Supporting reading materials10m
Supporting reading material10m
1 practice exercise
Module 3 Quiz30m
Week
4

Week 4

4 hours to complete

Module 4

4 hours to complete
15 videos (Total 148 min), 3 readings, 2 quizzes
15 videos
The Concept of Toxicological (Biological) Pathways, e.g., “Adverse Outcome Pathways,” Is the Basis of Predictive Toxicology5m
Introduction to the OECD AOP Framework10m
Building, Evaluating, and Using AOPs in Safety Decisions6m
Online Tools Available to Everyone, Including an Online AOP Course4m
Welcome to Module 42m
Introduction to Read-Across18m
Good Read-Across Practice21m
Supporting Read-Across with Biological Data12m
Creating a Database of Toxicity12m
Creating an Automated Tool for Read-Across9m
Paradigm Shift in Toxicology7m
2D In Vitro Cell Culture8m
3D In Vitro Cell Cultures8m
Organ-on-a-Chip11m
3 readings
Supporting reading material10m
Supporting reading material10m
Useful links10m
2 practice exercises
Module 4 Quiz30m
Mid-term exam30m
2 hours to complete

Module 5

2 hours to complete
6 videos (Total 41 min), 1 reading, 1 quiz
6 videos
MicroRNA and Epigenetics4m
Epigenetics and Environment6m
MicroRNA: Biogenesis and Functions11m
Role of MicroRNA in Development6m
MicroRNA in Toxicology9m
1 reading
Supporting reading material10m
1 practice exercise
Module 5 Quiz30m

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