Johns Hopkins University

Evidence-based Toxicology

Taught in English

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9,056 already enrolled


Gain insight into a topic and learn the fundamentals

Thomas Hartung
Lena Smirnova

Instructors: Thomas Hartung


(113 reviews)

Beginner level
No prior experience required
19 hours to complete
3 weeks at 6 hours a week
Flexible schedule
Learn at your own pace

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There are 7 modules in this course

This module introduces you to the course, outlines the shortcomings of current toxicity testing approaches, and shows how EBT can help to overcome these shortcomings.

What's included

9 videos3 readings1 quiz1 discussion prompt

This module explains how evidence-based toxicology originated and describes the driving forces for the initiative. In the second lesson, you will learn how to distinguish between correlation and causation as well as the main problems with drawing conclusions on the basis of correlations. The Bradford Hill criteria are introduced, along with examples for each criterion. You will also learn about mechanistic toxicology and mechanistic validation.

What's included

11 videos2 readings1 quiz1 discussion prompt

This module shows how to perform systematic reviews and meta-analyses. You will learn the history of both methods and will receive step-by-step instructions on how to perform systematic reviews and meta-analyses using examples from the research activities of the instructors.

What's included

8 videos2 readings2 quizzes1 discussion prompt

This module teaches you about possible biases that can be introduced at different stages of research. Each bias is explained with examples, including solutions for overcoming those biases. The second lesson covers systematic review of the zebrafish embryotoxicity test as a case study conducted by the Evidence-based Toxicology Collaboration (EBTC). You will go through all of the steps of the systematic review again to imprint the knowledge from module 3, but this systematic review will be related to a toxicological method.

What's included

8 videos2 readings1 quiz1 discussion prompt

Quality control is a very important aspect of not only modern toxicology but the entirety of life sciences. The first lesson in this module demonstrates the importance of performing quality control on your experiments. The second lesson is connected with the first one because validation of an alternative method requires highly standardized protocols and quality control at each step. This lesson teaches you different aspects of alternatives methods validation, how to perform classical validation, its pitfalls, and strategies to overcome them.

What's included

10 videos2 readings1 quiz1 discussion prompt

Evidence-based toxicology requires some knowledge of bioinformatics. The first lesson in the module teaches you some biostatistical tools you can apply when analyzing predectivity, specificity, and sensitivity of a method. You will also learn how to identify biases in a study with the help of bioinformatics. Evidence-based principles can be applied to every question you might have, even to which pizza to order tonight. You will learn the difference between eminence-based vs. evidence-based approaches. You will learn what is driving the lack of reproducibility and how evidence-based approaches should help to overcome the reproducibility crisis in science, which is explained with examples of experimental design, wrong models, poor quality of the cell cultures, etc.

What's included

8 videos1 reading2 quizzes1 discussion prompt

The final week of the course is devoted to completing the Systematic Review Assignment. You will use SysRev to review at least 20 abstracts, apply inclusion and exclusion criteria, render decisions, and resolve conflicts with other reviewers.

What's included

1 reading1 quiz1 plugin


Instructor ratings
4.7 (31 ratings)
Thomas Hartung
Johns Hopkins University
2 Courses16,969 learners
Lena Smirnova
Johns Hopkins University
2 Courses16,969 learners

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