About this Course
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Approx. 15 hours to complete

English

Subtitles: English

100% online

Start instantly and learn at your own schedule.

Flexible deadlines

Reset deadlines in accordance to your schedule.

Approx. 15 hours to complete

English

Subtitles: English

Syllabus - What you will learn from this course

Week
1
2 hours to complete

WEEK 1

Introduction to 'chronobiology'. What sorts of rhythms are observed in nature? Most of the lecture will be spent on describing daily or circadian rhythms in organisms from bacteria to man.

...
9 videos (Total 62 min), 1 reading, 2 quizzes
9 videos
1.1 The Family of Biological Rhythms 7m
1.2 The Circa-Rhythms5m
1.3 Spatial and Temporal Niches3m
1.4 The Case of Gonyaulax polyedra 6m
1.5 Introduction to the Second Half of Lecture 1 50s
1.6 Circadian Rhythms in Mammals 7m
1.7 Circadian Clocks in Flies, Plants and Fungi12m
1.8 Wrap up for Lecture 118m
1 reading
Literature suggestion10m
2 practice exercises
Lecture 1, Introduction, first half.10m
Lecture 1, Introduction, second half.10m
Week
2
1 hour to complete

WEEK 2

Circadian rhythms synchronise to the 24-hour environment. Organisms use specialised photoreceptors to do this and they display characteristic properties in this process. We experience this active synchronisation process for example when we suffer from jet lag!

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5 videos (Total 46 min), 3 readings, 1 quiz
5 videos
2.1 Pittendrigh´s generalisations 1-9 17m
2.2 Pittendrigh´s generalisations 10 and 11 7m
2.3 Pittendrigh´s generalisations 12-16 and entrainment11m
2.4 Wrap-up for Lecture 28m
3 readings
Literature suggestion10m
Translation of de Mairan's botanical observation5m
Obituary Jürgen Aschoff10m
1 practice exercise
Formalisms12m
Week
3
1 hour to complete

WEEK 3

We will discuss the elaborate molecular mechanisms that allow circadian clocks to produce their daily rhythms and to synchronise them to its environment. We will compare these mechanisms in a wide range of organisms.

...
8 videos (Total 62 min), 1 reading, 1 quiz
8 videos
3.1 The first clock gene8m
3.2 The negative feedback hypothesis 15m
3.3 More clock genes -many more! 5m
3.4 Post transcriptional mechanisms and the clock 11m
3.5 Indications of a non-transcriptional clock 6m
3.6 Zeitgebers and the molecular clockwork9m
3.7 Wrap-up to Lecture 34m
1 reading
Literature suggestion10m
1 practice exercise
Lecture 3 Molecular mechanisms12m
Week
4
1 hour to complete

WEEK 4

Circadian clocks serve to orchestrate physiology and metabolism in a coordinated way over the course of the day. Therefore, practically all processes in an organism are regulated outputs of the clock. We'll discuss examples of these processes and ideas about how this circadian regulation works.

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8 videos (Total 60 min), 1 reading, 1 quiz
8 videos
4.1 Clock control: which processes in humans and how to measure them? 10m
4.2 Schwänzeltanz 5m
4.3 The SCN regulates the timing of physiology and behaviour 3m
4.4 Clock controlled genes (ccg´s) 14m
4.5 Clock regulation of behaviour: genetic mechanisms 5m
4.6 Clock regulation of other major regulatory systems 4m
4.7 Wrap-Up to Lecture 414m
1 reading
Literature suggestion10m
1 practice exercise
Lecture 4: Clock control10m
Week
5
1 hour to complete

WEEK 5

With the appreciation of the clock’s global control, we proceed to discussing how much this temporal programme controls our lives from birth to death and how much we mistreat the circadian clock in modern life.

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6 videos (Total 58 min), 1 reading, 1 quiz
6 videos
5.1 Chronotypes11m
5.2 What makes up Chronotypes?8m
5.3 Linking chronotype and light entrainment12m
5.4 How modern life styles affect sleep7m
5.5 Wrap-up to Lecture 516m
1 reading
The link to the MCTQ10m
1 practice exercise
Human12m
Week
6
5 hours to complete

WEEK 6

Finally, we will look at the clock’s relationship to pathology. What are the consequences of living against the clock, what happens if the clock ‘breaks’, and how can we use our knowledge about the circadian system in medical diagnosis and therapy.

...
11 videos (Total 77 min), 4 quizzes
11 videos
6.1 What is normal and what not and why? 9m
6.2 The consequences of living against the clock11m
6.3 Circadian changes and Pathologies - comorbidities or causal factors 3m
6.4 Introduction to the Second Half of Lecture 6 1m
6.5 Clock genes that can really mess up the timing of sleep8m
6.6 The clock gene mutant mice are sick 8m
6.7 Chronopharmacology and chronochemotherapy 4m
6.8 The circadian clock is a fitness characteristic8m
6.9 Wrap-up to Lecture 613m
6.10 Farewell from your CircaClock Team 6m
3 practice exercises
Final Exam "Circaclock"58m
Pathology8m
Lecture 6. Clock and pathologies8m

Instructors

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Martha Merrow

Professor
Medical Psychology
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Till Roenneberg

Professor
Medical Psychology

About Ludwig-Maximilians-Universität München (LMU)

As one of Europe's leading research universities, LMU Munich is committed to the highest international standards of excellence in research and teaching. Building on its 500-year-tradition of scholarship, LMU covers a broad spectrum of disciplines, ranging from the humanities and cultural studies through law, economics and social studies to medicine and the sciences....

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