Technical University of Denmark (DTU)
Introduction to Industrial Bioprocess Development
Technical University of Denmark (DTU)

Introduction to Industrial Bioprocess Development

Taught in English

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9,039 already enrolled

Course

Gain insight into a topic and learn the fundamentals

Giuliano M. Dragone

Instructor: Giuliano M. Dragone

4.7

(150 reviews)

Beginner level
No prior experience required
15 hours to complete
3 weeks at 5 hours a week
Flexible schedule
Learn at your own pace

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5 quizzes

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There are 5 modules in this course

In Module 1 you will find an introduction to some properties of microorganisms. Microorganisms are essential for the development of industrial bioprocesses. You will learn how they are used in fermentation processes for conversion of sugars into ethanol, e.g., for beer or vinegar production. Major discoveries during the 19th and 20th centuries that led to the bioproduction of antibiotics and chemicals on an industrial scale are also covered in this Module. A discussion on the use of recombinant proteins, metabolic engineering and commercial production of bioethanol is presented in the last part of the Module.

What's included

5 videos2 readings1 quiz

Industrial fermentation processes are largely classified as batch, fed-batch or continuous operations. In Module 2 you will learn the main characteristics of these three operation modes. This Module also covers the advantages and disadvantages of each type of bioreactor operation.

What's included

3 videos1 reading1 quiz

In Module 3, you will learn about the different sources and roles of individual components of fermentation media. A well-designed fermentation medium is critical to the ultimate success of industrial bioprocesses at industrial scale. Students will be also introduced to the most common sterilization methods used in biomanufacturing processes at lab and industrial scale. In addition, we will be looking at different preservation techniques of microbial cultures. The Module will end up describing some requirements needed for the preparation of an inoculum to be used in the production stage.

What's included

4 videos1 reading1 quiz

In this Module we will look at the different types of bioreactors that are commonly used for biomanufacturing processes at industrial scale. Module 4 also covers the main processes parameters that affect the development of a bioprocess in Stirred Tank Reactors (STRs). We will also explore the most common strategies to scale up a bioprocess in order to reach the production-scale level in the most efficient and economical manner.

What's included

3 videos1 reading1 quiz

Module 5 will cover the main stages of downstream processing of bioproducts. Along with the review of common operations used for primary isolation, this Module will present detailed case studies showcasing the complexity required to obtain both extracellular (lactic acid) and intracellular (enzymes) products.

What's included

3 videos1 reading1 quiz

Instructor

Instructor ratings
4.5 (58 ratings)
Giuliano M. Dragone
Technical University of Denmark (DTU)
1 Course9,039 learners

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