About this Course
4.8
42 ratings
10 reviews
The objective of this course is to give students the most up-to-date information on the biological, personal, and societal relevance of sleep. Personal relevance is emphasized by the fact that the single best predictor of daytime performance is the quality of the previous night's sleep. The brain actively generates sleep, and the first section of the course is an overview of the neurobiological basis of sleep control. The course provides cellular-level understanding of how sleep deprivation, jet lag, and substances such as alcohol, ,caffeine, and nicotine alter sleep and wakefulness. The second section of the course covers sleep-dependent changes in physiology and sleep disorders medicine. Particular emphasis will be placed on disorders of excessive sleepiness, insomnia, and sleep-dependent changes in autonomic control. Chronic sleep deprivation impairs immune function and may promote obesity. Deaths due to all causes are most frequent between 4:00 and 6:00 a.m., and this second section of the class highlights the relevance of sleep for preventive medicine. The societal relevance of sleep will be considered in the final section of the class. In an increasingly complex and technologically oriented society, operator-error by one individual can have a disastrous negative impact on public health and safety. Fatigue-related performance decrements are known to have contributed as causal factors to nuclear power plant failures, transportation disasters, and medical errors....
Globe

100% online courses

Start instantly and learn at your own schedule.
Calendar

Flexible deadlines

Reset deadlines in accordance to your schedule.
Beginner Level

Beginner Level

Clock

Suggested: 5 hours/week

Approx. 19 hours to complete
Comment Dots

English

Subtitles: English
Globe

100% online courses

Start instantly and learn at your own schedule.
Calendar

Flexible deadlines

Reset deadlines in accordance to your schedule.
Beginner Level

Beginner Level

Clock

Suggested: 5 hours/week

Approx. 19 hours to complete
Comment Dots

English

Subtitles: English

Syllabus - What you will learn from this course

1

Section
Clock
2 hours to complete

Unit 01 - Neurobiology Section: Course Introduction & Neurobiology of Sleep and Wakefulness (Part One) - (Standard Track & Honors Track)

This unit begins with a Course Overview video from Ralph Lydic, Ph.D., followed by the first portion of the Neurobiology of Sleep and Wakefulness lecture, delivered by Helen Baghdoyan, Ph.D. PLEASE NOTE: Only the Course Overview video, and the Getting Started and Syllabus readings are required for students who have chosen to engage in the Standard Track portion of the course content. Standard track students may also bypass all content in units 2, 3, and 4, and instead move directly to unit 5 after viewing the Course Overview video....
Reading
6 videos (Total 93 min), 4 readings, 1 quiz
Video6 videos
02.01 - Learning Points14m
02.02 - Defining Behavioral States8m
02.03 - Historical Overview: Brainstem & Forebrain17m
02.04 - Wake & REM: Monoamines17m
02.05 - Wake & REM: Acetylcholine17m
Reading4 readings
Getting Started10m
Syllabus10m
Help Us Learn More About You!10m
Lesson 2 Orientation10m
Quiz1 practice exercise
Did you Complete Lesson 2?2m

2

Section
Clock
2 hours to complete

Unit 02 - Neurobiology Section: Neurobiology of Sleep and Wakefulness (Part Two) - (Honors Track)

Unit 2 continues the lecture from Helen Baghdoyan, Ph.D. on the Neurobiology of Sleep and Wakefulness. PLEASE NOTE: This content is only required for students who have chosen to pursue the Honors Track certification....
Reading
5 videos (Total 73 min), 2 quizzes
Video5 videos
02.07: Wake & REM: Orexin17m
02.08: NREM: GABA14m
02.09: NREM: Adenosine 11m
02:10: Summary12m
Quiz2 practice exercises
Did you complete Lesson 03?2m
Unit 02 Honors Track Quiz - Neurobiology of Sleep and Wakefulness30m

3

Section
Clock
1 hour to complete

Unit 03 - Neurobiology: Mathematical Modeling of Sleep-Wake Regulation - (Honors Track)

Unit 3 continues the Neurobiology section of the content with a lecture from Victoria Booth, Ph.D. on the Mathematical Modeling of Sleep-Wake Regulation. PLEASE NOTE: This content is only required for students who have chosen to pursue the Honors Track certification....
Reading
10 videos (Total 67 min), 1 reading, 2 quizzes
Video10 videos
03.02 - Two Process Model 5m
03.03 - Sleep-Wake Flip-Flop Model5m
03.04 - Reciprocal Interaction Model 12m
03.05 - REM Sleep Flip-Flop Model4m
03.06 - Features for an Ideal Model of Sleep-Wake Regulation7m
03.07 - Introduction to Mechanistic Models of Sleep-Wake Regulation 3m
03.08 - Diniz Benh & Booth Model - Part I9m
03.09 - Diniz Benh & Booth Model - Part II 14m
03.10 - Conclusion 1m
Reading1 reading
Unit 03 Orientation10m
Quiz2 practice exercises
Did you Complete Lesson 5?2m
Unit 03 Quiz - Mathematical Modeling of Sleep-Wake Regulation10m

4

Section
Clock
1 hour to complete

Unit 04 - Neurobiology: Molecular Biology and Genetics of Sleep - (Honors Track)

Unit 4 closes out the Neurobiology section with a lecture from Chiara Cirelli, Ph.D. on Molecular Biology and the Genetics of Sleep. PLEASE NOTE: This content is only required for students who have chosen to pursue the Honors Track certification....
Reading
6 videos (Total 52 min), 2 quizzes
Video6 videos
04.02 - Wake Genes that are Associated with Energy Metabolism 7m
04.03 - Synaptic Plasticity is Genetically Modulated 7m
04.04 - Brain Glial Cells Influence States of Sleep and Wakefulness 9m
04.05 - Genetic Modulation of Human Sleep Phenotypes 8m
04.06 - Conclusion 11m
Quiz2 practice exercises
Did you complete Lesson 7?2m
Unit 04 Quiz - Molecular Biology and Genetics of Sleep10m
4.8

Top Reviews

By JQJan 3rd 2018

Excellent course! A great review on stuff I should have remembered but of course have forgotten as I've aged. My thanks to those organizing and teaching the course! Dr Quincy

By DFFeb 19th 2018

I thoroughly enjoyed this course and look forward to continuing my education on the subject.

Instructors

Ralph Lydic, Ph.D.

Professor Emeritus, Molecular and Integrative Physiology, Professor Emeritus, Anesthesiology
University of Michigan Medical School

Helen Baghdoyan, Ph.D.

Professor Emeritus, Anesthesiology, Professor Emeritus, Pharmacology, Professor of Psychiatry
University of Michigan Medical School

About University of Michigan

The mission of the University of Michigan is to serve the people of Michigan and the world through preeminence in creating, communicating, preserving and applying knowledge, art, and academic values, and in developing leaders and citizens who will challenge the present and enrich the future....

Frequently Asked Questions

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

More questions? Visit the Learner Help Center.