Johns Hopkins University

Understanding Cancer Metastasis

This course is part of Cancer Biology Specialization

Kenneth J. Pienta, M.D.
Jelani Zarif
Sarah Amend

Instructors: Kenneth J. Pienta, M.D.

61,247 already enrolled

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Gain insight into a topic and learn the fundamentals.
4.9

(2,417 reviews)

Beginner level
No prior experience required
Flexible schedule
Approx. 5 hours
Learn at your own pace
97%
Most learners liked this course
Gain insight into a topic and learn the fundamentals.
4.9

(2,417 reviews)

Beginner level
No prior experience required
Flexible schedule
Approx. 5 hours
Learn at your own pace
97%
Most learners liked this course

Details to know

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Assessments

6 quizzes

Taught in English

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This course is part of the Cancer Biology Specialization
When you enroll in this course, you'll also be enrolled in this Specialization.
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There are 6 modules in this course

In this first module, we'll concentrate on the history and overview of metastasis and give you a flavor of how cancer is defined as well as some of the history surrounding how we began to understand metastasis.

What's included

5 videos1 quiz

In this module, we'll focus on uncontrolled cell division, which is a defining property of cancer, as well as mutation and neoangiogenesis and their roles in tumor formation. We'll also take a look at a primary tumor microenvironment and its component cell types.

What's included

5 videos1 quiz

During this module, we'll turn our attention to the next steps after the initial primary tumor formation, epithelial to mesenchymal transition of cancer cells, and local tumor invasion and intravasation into blood or lymph vessels.

What's included

4 videos1 quiz

We'll now take a close look at cancer survival within the circulation, the role of the circulatory system in metastasis, the genetic determinants of metastatic potential, signalling mechanisms, chemokines, the dock and lock hypothesis, and extravasation.

What's included

6 videos1 quiz

In this module, we'll focus on dormancy and secondary tumor growth and how they contribute to the lethality of cancer.

What's included

6 videos1 quiz

In the previous modules, we've looked closely at the sequential steps of metastasis and some of the biology of how metastasis occurs. Now, we'll turn our attention to morbidity and mortality, or in other words, how cancer hurts and kills people.

What's included

4 videos1 quiz

Instructors

Instructor ratings
4.9 (588 ratings)
Kenneth J. Pienta, M.D.
Johns Hopkins University
3 Courses235,264 learners
Jelani Zarif
Johns Hopkins University
1 Course61,247 learners
Sarah Amend
Johns Hopkins University
1 Course61,247 learners

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