This course is part of the Systems Biology and Biotechnology Specialization

4.2
stars
533 ratings

Ravi Iyengar, PhD

43,345 already enrolled

Offered By

Systems Biology and Biotechnology SpecializationIcahn School of Medicine at Mount Sinai

About this Course

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This course will introduce the student to contemporary Systems Biology focused on mammalian cells, their constituents and their functions. Biology is moving from molecular to modular. As our knowledge of our genome and gene expression deepens and we develop lists of molecules (proteins, lipids, ions) involved in cellular processes, we need to understand how these molecules interact with each other to form modules that act as discrete functional systems. These systems underlie core subcellular processes such as signal transduction, transcription, motility and electrical excitability. In turn these processes come together to exhibit cellular behaviors such as secretion, proliferation and action potentials. What are the properties of such subcellular and cellular systems? What are the mechanisms by which emergent behaviors of systems arise? What types of experiments inform systems-level thinking? Why do we need computation and simulations to understand these systems?
The course will develop multiple lines of reasoning to answer the questions listed above. Two major reasoning threads are: the design, execution and interpretation of multivariable experiments that produce large data sets; quantitative reasoning, models and simulations. Examples will be discussed to demonstrate “how” cell- level functions arise and “why” mechanistic knowledge allows us to predict cellular behaviors leading to disease states and drug responses.

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Includes hands on learning projects.

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Course 1 of 6 in the

Systems Biology and Biotechnology Specialization

Approx. 19 hours to complete

English

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Flexible deadlines

Reset deadlines in accordance to your schedule.

Shareable Certificate

Earn a Certificate upon completion

100% online

Start instantly and learn at your own schedule.

Coursera Labs

Includes hands on learning projects.

Learn more about Coursera Labs

Course 1 of 6 in the

Systems Biology and Biotechnology Specialization

Approx. 19 hours to complete

English

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Instructor

Instructor rating

4.25/5 (72 Ratings)

Ravi Iyengar, PhD

Dorothy H. and Lewis Rosenstiel Professor

Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York (SBCNY)

43,398 Learners

2 Courses

Offered by

Icahn School of Medicine at Mount Sinai

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Syllabus - What you will learn from this course

Content Rating94%(3,093 ratings)

Week1

Week 1

2 hours to complete

Systems Level Reasoning | Molecules to Pathways

2 hours to complete

5 videos (Total 71 min), 3 readings, 1 quiz

Week2

Week 2

2 hours to complete

Pathways to Networks | Physical Forces and Electrical Activity in Cell Biology

2 hours to complete

4 videos (Total 66 min), 3 readings, 1 quiz

Week3

Week 3

2 hours to complete

Mathematical Representations of Cell Biological Systems | Simulations of Cell Biological Systems

2 hours to complete

4 videos (Total 61 min), 3 readings, 1 quiz

Week4

Week 4

2 hours to complete

Experimental Technologies | Network Building and Analysis

2 hours to complete

4 videos (Total 76 min), 4 readings, 1 quiz

Week5

Week 5

1 hour to complete

Midterm

1 hour to complete

Week6

Week 6

2 hours to complete

Analysis of Networks | Topology to Function

2 hours to complete

4 videos (Total 70 min), 3 readings, 1 quiz

Week7

Week 7

2 hours to complete

Strengths and Limitations of Different Types of Models | Identifying Emergent Properties

2 hours to complete

4 videos (Total 71 min), 4 readings, 1 quiz

4 videos

Strengths and Limitations of Different Types of Models I12mStrengths and Limitations of Different Types of Models II22mIdentifying Emergent Properties: Bistability I18mIdentifying Emergent Properties: Bistability II17m

4 readings

Lecture Slides10mLecture Slides10mLecture Slides10mLecture Slides10m

1 practice exercise

Strengths and Limitations of Different Types of Models | Identifying Emergent Properties30m

Week8

Week 8

2 hours to complete

Emergent Properties: Ultrasensitivity and Robustness | Case Studies

2 hours to complete

4 videos (Total 75 min), 4 readings, 1 quiz

Week9

Week 9

3 hours to complete

Case Studies | Systems Biomedicine | Systems Pharmacology and Therapeutics | Perspective

3 hours to complete

5 videos (Total 87 min), 4 readings, 1 quiz

Week10

Week 10

1 hour to complete

Final

1 hour to complete

Reviews

4.2

111 reviews

5 stars
56.28%
4 stars
25.51%
3 stars
9%
2 stars
5.06%
1 star
4.12%

TOP REVIEWS FROM INTRODUCTION TO SYSTEMS BIOLOGY

by DEMay 6, 2017

Very nice course, would have liked more interactivity / problem solving type questions

by PLNov 15, 2020

This course has been a very instructive course for me. I would like to thank ISM and Dr. Iyengar for his sacrifice for sharing his knowledge!!!

by EOFeb 6, 2016

Nice course, a little boring at the beginning with so much data about cell signaling, (kinases names, and specific routes).

by AFJan 25, 2018

This course was very engaging and extremely insightful.

View all reviews

About the Systems Biology and Biotechnology Specialization

Design systems-level experiments using appropriate cutting edge techniques, collect big data, and analyze and interpret small and big data sets quantitatively.

The Systems Biology Specialization covers the concepts and methodologies used in systems-level analysis of biomedical systems. Successful participants will learn how to use experimental, computational and mathematical methods in systems biology and how to design practical systems-level frameworks to address questions in a variety of biomedical fields. In the final Capstone Project, students will apply the methods they learned in five courses of specialization to work on a research project.

Frequently Asked Questions

When will I have access to the lectures and assignments?
Access to lectures and assignments depends on your type of enrollment. If you take a course in audit mode, you will be able to see most course materials for free. To access graded assignments and to earn a Certificate, you will need to purchase the Certificate experience, during or after your audit. If you don't see the audit option:
The course may not offer an audit option. You can try a Free Trial instead, or apply for Financial Aid.
The course may offer 'Full Course, No Certificate' instead. This option lets you see all course materials, submit required assessments, and get a final grade. This also means that you will not be able to purchase a Certificate experience.
What will I get if I subscribe to this Specialization?
When you enroll in the course, you get access to all of the courses in the Specialization, and you earn a certificate when you complete the work. Your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.
Is financial aid available?
Yes. In select learning programs, you can apply for financial aid or a scholarship if you can’t afford the enrollment fee. If fin aid or scholarship is available for your learning program selection, you’ll find a link to apply on the description page.

More questions? Visit the Learner Help Center.

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Introduction to Systems Biology

About this Course