This course covers the stages of drug discovery in which promising compounds (leads) are identified, their optimal and suboptimal characteristics determined, and the suboptimal characteristics optimized to create a candidate suitable for the clinic. The course is built around a case study on the discovery of an antimalarial therapy. Assays useful for screening new compounds are outlined, examples of selection criteria for leads are discussed - such as potency, efficacy, and pharmacokinetics - and the structure activity relationships that contribute to the optimization of a lead series are considered. The phenotypic approach used by the antimalarial program will be briefly contrasted with a target-based program on a different target.
Lead Selection & Optimization
Lead Selection & Optimization
This course is part of Drug Hunting: The Science of Making New Medicines Specialization
Instructors: Erland Stevens, PhD
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Gain insight into a topic and learn the fundamentals.
31 reviews
Intermediate level
Recommended experience
8 hours to complete
Flexible schedule
Learn at your own pace
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Assessments
12 assignments
Taught in English
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This course is part of the Drug Hunting: The Science of Making New Medicines Specialization
When you enroll in this course, you'll also be enrolled in this Specialization.
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There are 3 modules in this course
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EK
Reviewed on Sep 3, 2024
Key concepts covered in a concise and accessible format.
GS
Reviewed on Nov 30, 2024
It is a perfect course with ample knowledge and testing of knowledge by quizzes and discussions.
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