About this Course

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Intermediate Level

Basic training in chemistry biology and physics.

Approx. 21 hours to complete
English

What you will learn

  • Foundational comprehension of chemical biology

  • Interfacial science problem solving and method design

  • Understanding of applied, translational concepts in life sciences

Shareable Certificate
Earn a Certificate upon completion
100% online
Start instantly and learn at your own schedule.
Flexible deadlines
Reset deadlines in accordance to your schedule.
Intermediate Level

Basic training in chemistry biology and physics.

Approx. 21 hours to complete
English

Offered by

Placeholder

University of Geneva

Syllabus - What you will learn from this course

Week
1

Week 1

4 hours to complete

Welcome to Chemical Biology: Concepts and techniques

4 hours to complete
8 videos (Total 58 min), 7 readings, 4 quizzes
8 videos
Welcome1m
Why study chemical biology?11m
Course outline and highlights9m
The building blocks: monomeric units of proteins9m
The building blocks: monomeric units of DNA and membranes8m
Messengers and messages: posttranslational modifications, and pathways8m
Studying cellular processes with chemical biology in real time8m
7 readings
Course Acknowledgements5m
How assessments work10m
The foundation: the cell10m
The workhorses: proteins, enzymes12m
Classical protein readouts12m
Flash mob: overview of protein analysis methods10m
Flash mob - Chemistry15m
4 practice exercises
Components of a cell22m
Amino acids24m
Match technique to goal15m
Final Quiz Number 128m
Week
2

Week 2

3 hours to complete

The Devil is in the Minutest Detail

3 hours to complete
5 videos (Total 37 min), 5 readings, 3 quizzes
5 videos
Light'em up! Fluorophores: structures, and fluorescent principles9m
Get out (almost) what you put in!3m
Traditional light microscopy – applications10m
Traditional light microscopy – precautions10m
5 readings
Physics of fluorescence15m
Fluorescent proteins10m
RNA interference and genome editing20m
Plasmids and transfection15m
DNA double stranded breaks and γ-H2AX10m
3 practice exercises
Jablonski diagram16m
Match color of fluorophore to structure20m
Final Quiz Number 222m
Week
3

Week 3

4 hours to complete

A ruler over time and space! Fluorescent assays to measure complex parameters in real time

4 hours to complete
12 videos (Total 88 min), 5 readings, 6 quizzes
12 videos
Creating modified chromatin 9m
PRC2, a DNA binding complex linked to development and cancer7m
TIRF talk7m
On our TIRF4m
If your protein surfs on DNA, hit the TIRF to study it8m
PHF1 Prolongs the stable PRC2-DNA complex, promoting activity8m
Fluid mosaic model5m
Don’t get uptight! New methods to measure membrane tension7m
Getting a grip on membrane tension measurements4m
TORCing TORC: the many faces of the TOR proteins8m
TORCing it out: pathways that seek to sense and restore membrane tension13m
5 readings
DNA organization in eukaryotes is linked to regulation10m
Kinetics of chemical reactions6m
Comparing chemical structures6m
Flash mob inteins6m
Model Organisms20m
6 practice exercises
Making proteins via expressed protein ligation and alkylation18m
Hit the tirf: applications of TIRF microscopy11m
Analyzing data from TIRF experiments to gain mechanistic insights17m
Modern fluorescence methods, the spark of creativity15m
TORCing about Tor's role in membrane tension regulation16m
Final Quiz 325m
Week
4

Week 4

5 hours to complete

Putting proteins to work for us

5 hours to complete
11 videos (Total 95 min), 2 readings, 7 quizzes
11 videos
Tracking a specific protein in live cells & in real time8m
Molecular zipcodes4m
How to design your fusion protein6m
Design principle and optimization of SNIFITs7m
SNIFITs to ID neurotransmitters and drugs10m
Application to point of care diagnosis7m
Biological electrophiles, the cell’s way of saying “I’m stressed”?8m
Breaking the tether is not that bad10m
T-REX: a question of control(s)16m
T-REX rewiring of kinase activity through targeting AKT and PTEN: opposing forces meet 10m
2 readings
Many enzyme mechanisms proceed through a covalent enzyme intermediate that can be stabilized through mutagenesis10m
Small molecule signals8m
4 practice exercises
Optimal considerations for making fusion proteins and employing them in chemical biology24m
Optimal considerations for making fusion proteins and employing them in chemical biology214m
A bit on the nose? Chose the right SNIFITs20m
Final Quiz Number 424m

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