About this Course
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Flexible deadlines

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Approx. 30 hours to complete

Suggested: 7 weeks of study, 6-8 hours/week...

English

Subtitles: English, Spanish

Skills you will gain

CancerMolecular BiologyCancer EpigeneticsDna Methylation
Learners taking this Course are
  • Biologists
  • Paramedics
  • Nutritionists
  • Scientists
  • Biostatisticians

100% online

Start instantly and learn at your own schedule.

Flexible deadlines

Reset deadlines in accordance to your schedule.

Approx. 30 hours to complete

Suggested: 7 weeks of study, 6-8 hours/week...

English

Subtitles: English, Spanish

Syllabus - What you will learn from this course

Week
1
2 hours to complete

Week 1 - Introduction to Epigenetic Control

7 videos (Total 65 min), 5 readings, 1 quiz
7 videos
1.1 Introduction to the concepts of epigenetic control10m
1.2 Mitotic heritability of epigenetic marks10m
1.3 Chromatin and the nucleosome6m
1.4 Chromatin compaction - heterochromatin versus euchromatin9m
1.5 DNA methylation at CpG islands11m
1.6 DNA methylation at intergenic regions and repetitive elements15m
5 readings
Course syllabus10m
Teaching team10m
Start of course survey10m
Assessment and grading policy10m
Week 1 and 2 resources10m
1 practice exercise
Week 1 quiz - contributes 8% towards your final grade20m
Week
2
2 hours to complete

Week 2 - Epigenetic Modifications and Organisation of the Nucleus

9 videos (Total 90 min), 1 reading, 1 quiz
9 videos
2.2 Histone acetylation and histone methylation12m
2.3 Chromatin remodelling12m
2.4 Histone variants8m
2.5 Noncoding RNAs - microRNAs6m
2.6 Noncoding RNAs - piRNAs9m
2.7 Noncoding RNAs - long noncoding RNAs introduction10m
2.8 Long noncoding RNAs Xist and HOTAIR7m
2.9 3D organisation of the nucleus and summary of epigenetic marks17m
1 reading
Week 1 and 2 resources10m
1 practice exercise
Week 2 quiz - contributes 8% towards your final grade20m
Week
3
3 hours to complete

Week 3 - Dosage Compensation

12 videos (Total 113 min), 1 reading, 1 quiz
12 videos
3.2 Timing of random and imprinted X chromosome inactivation8m
3.3 Stages of X inactivation - counting and control of Xist expression13m
3.4 Control of Xist expression by pluripotency factors6m
3.5 Stages of X inactivation - choice of which X to inactivate9m
3.6 Stages of X inactivation - initiation and spreading of silencing11m
3.7 Stages of X inactivation - establishment of silencing6m
3.8 Stages of X inactivation - maintenance of silencing e.g. Dnmt18m
3.9 Stages of X inactivation - maintenance of silencing e.g. Smchd18m
3.10 X chromosome inactivation summary10m
3.11 Dosage compensation in flies and worms, compared with mammals8m
3.12 Lessons from the fly - position effect variegation and screening for epigenetic modifiers10m
1 reading
Week 3 resources (including required readings)10m
1 practice exercise
Week 3 quiz - contributes 12% towards your final grade30m
Week
4
2 hours to complete

Week 4 - Genomic Imprinting and Epigenetic Reprogramming

6 videos (Total 68 min), 1 reading, 1 quiz
6 videos
4.2 Epigenetic reprogramming of imprinted genes and repetitive elements11m
4.3 Location of imprinted genes in the genome and bisulfite sequencing10m
4.4 Kcnq1 and H19/Igf2 ICR mechanisms of action and Beckwith Weidemann syndrome17m
4.5 Snrpn ICR mechanism, Prader Willi and Angelman syndromes13m
4.6 Summary of epigenetic reprogramming and imprinting6m
1 reading
Week 4 resources (including required reading)10m
1 practice exercise
Week 4 quiz - contributes 12% towards your final grade30m
4.8
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Top reviews from Epigenetic Control of Gene Expression

By MMOct 2nd 2018

This was an excellent course. All the material was well presented and the explanation of the sometimes complex subject matter was clear and understandable. Thank you for an great learning experience.

By DSAug 25th 2018

This is an excellent course that introduces you to fundamental knowledge of several hot topics in the field of epigenetics. Dr. Blewitt herself studies X inactivation, and I learned so much!

Instructor

Avatar

Dr. Marnie Blewitt

Head, Molecular Medicine Laboratory
Walter and Eliza Hall Institute of Medical Research

About The University of Melbourne

The University of Melbourne is an internationally recognised research intensive University with a strong tradition of excellence in teaching, research, and community engagement. Established in 1853, it is Australia's second oldest University....

Frequently Asked Questions

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  • When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

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