About this Course

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Learner Career Outcomes

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started a new career after completing these courses

38%

got a tangible career benefit from this course

11%

got a pay increase or promotion
Shareable Certificate
Earn a Certificate upon completion
100% online
Start instantly and learn at your own schedule.
Flexible deadlines
Reset deadlines in accordance to your schedule.
Approx. 18 hours to complete
English
Subtitles: English, Spanish

Skills you will gain

CancerMolecular BiologyCancer EpigeneticsDna Methylation

Learner Career Outcomes

33%

started a new career after completing these courses

38%

got a tangible career benefit from this course

11%

got a pay increase or promotion
Shareable Certificate
Earn a Certificate upon completion
100% online
Start instantly and learn at your own schedule.
Flexible deadlines
Reset deadlines in accordance to your schedule.
Approx. 18 hours to complete
English
Subtitles: English, Spanish

Offered by

The University of Melbourne logo

The University of Melbourne

Syllabus - What you will learn from this course

Content RatingThumbs Up97%(6,055 ratings)Info
Week
1

Week 1

2 hours to complete

Week 1 - Introduction to Epigenetic Control

2 hours to complete
7 videos (Total 65 min), 5 readings, 1 quiz
7 videos
1.1 Introduction to the concepts of epigenetic control10m
1.2 Mitotic heritability of epigenetic marks10m
1.3 Chromatin and the nucleosome6m
1.4 Chromatin compaction - heterochromatin versus euchromatin9m
1.5 DNA methylation at CpG islands11m
1.6 DNA methylation at intergenic regions and repetitive elements15m
5 readings
Course syllabus10m
Teaching team10m
Start of course survey10m
Assessment and grading policy10m
Week 1 and 2 resources10m
1 practice exercise
Week 1 quiz - contributes 8% towards your final grade20m
Week
2

Week 2

2 hours to complete

Week 2 - Epigenetic Modifications and Organisation of the Nucleus

2 hours to complete
9 videos (Total 90 min), 1 reading, 1 quiz
9 videos
2.2 Histone acetylation and histone methylation12m
2.3 Chromatin remodelling12m
2.4 Histone variants8m
2.5 Noncoding RNAs - microRNAs6m
2.6 Noncoding RNAs - piRNAs9m
2.7 Noncoding RNAs - long noncoding RNAs introduction10m
2.8 Long noncoding RNAs Xist and HOTAIR7m
2.9 3D organisation of the nucleus and summary of epigenetic marks17m
1 reading
Week 1 and 2 resources10m
1 practice exercise
Week 2 quiz - contributes 8% towards your final grade20m
Week
3

Week 3

3 hours to complete

Week 3 - Dosage Compensation

3 hours to complete
12 videos (Total 113 min), 1 reading, 1 quiz
12 videos
3.2 Timing of random and imprinted X chromosome inactivation8m
3.3 Stages of X inactivation - counting and control of Xist expression13m
3.4 Control of Xist expression by pluripotency factors6m
3.5 Stages of X inactivation - choice of which X to inactivate9m
3.6 Stages of X inactivation - initiation and spreading of silencing11m
3.7 Stages of X inactivation - establishment of silencing6m
3.8 Stages of X inactivation - maintenance of silencing e.g. Dnmt18m
3.9 Stages of X inactivation - maintenance of silencing e.g. Smchd18m
3.10 X chromosome inactivation summary10m
3.11 Dosage compensation in flies and worms, compared with mammals8m
3.12 Lessons from the fly - position effect variegation and screening for epigenetic modifiers10m
1 reading
Week 3 resources (including required readings)10m
1 practice exercise
Week 3 quiz - contributes 12% towards your final grade30m
Week
4

Week 4

2 hours to complete

Week 4 - Genomic Imprinting and Epigenetic Reprogramming

2 hours to complete
6 videos (Total 68 min), 1 reading, 1 quiz
6 videos
4.2 Epigenetic reprogramming of imprinted genes and repetitive elements11m
4.3 Location of imprinted genes in the genome and bisulfite sequencing10m
4.4 Kcnq1 and H19/Igf2 ICR mechanisms of action and Beckwith Weidemann syndrome17m
4.5 Snrpn ICR mechanism, Prader Willi and Angelman syndromes13m
4.6 Summary of epigenetic reprogramming and imprinting6m
1 reading
Week 4 resources (including required reading)10m
1 practice exercise
Week 4 quiz - contributes 12% towards your final grade30m

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Frequently Asked Questions

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