This course introduces you to the basic biology of modern genomics and the experimental tools that we use to measure it. We'll introduce the Central Dogma of Molecular Biology and cover how next-generation sequencing can be used to measure DNA, RNA, and epigenetic patterns. You'll also get an introduction to the key concepts in computing and data science that you'll need to understand how data from next-generation sequencing experiments are generated and analyzed.
This course is part of the Genomic Data Science Specialization
Offered By
Genomic Data Science SpecializationJohns Hopkins UniversityAbout this Course
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Learner Career Outcomes
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started a new career after completing these courses
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got a tangible career benefit from this course
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Approx. 6 hours to complete
English
Subtitles: Arabic, French, Portuguese (European), Chinese (Simplified), Italian, Vietnamese, Korean, German, Russian, Turkish, English, Spanish
Skills you will gain
BioinformaticsStatisticsData ScienceComputational Biology
Learner Career Outcomes
30%
started a new career after completing these courses
24%
got a tangible career benefit from this course
Shareable Certificate
Earn a Certificate upon completion
100% online
Start instantly and learn at your own schedule.
Course 1 of 8 in the
Flexible deadlines
Reset deadlines in accordance to your schedule.
Approx. 6 hours to complete
English
Subtitles: Arabic, French, Portuguese (European), Chinese (Simplified), Italian, Vietnamese, Korean, German, Russian, Turkish, English, Spanish
Offered by
Johns Hopkins University
The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.
Syllabus - What you will learn from this course
2 hours to complete
Overview
In this Module, you can expect to study topics of "Just enough molecular biology", "The genome", "Writing a DNA sequence", "Central dogma", "Transcription", "Translation", and "DNA structure and modifications".
2 hours to complete
8 videos (Total 81 min), 2 readings, 1 quiz
8 videos
What Is Genomics?7m
What Is Genomic Data Science?8m
Just Enough Cell Biology8m
Important Molecules in Molecular Biology7m
The Human Genome Project17m
Molecular Biology Structures9m
From Genes to Phenotypes9m
2 readings
Syllabus10m
Pre-Course Survey10m
1 practice exercise
Quiz 1: Overview and Molecular Biology30m
1 hour to complete
Measurement Technology
In this module, you'll learn about polymerase chain reaction, next generation sequencing, and applications of sequencing.
1 hour to complete
3 videos (Total 25 min)
1 practice exercise
Quiz 2: Measurement Technology30m
1 hour to complete
Computing Technology
The lectures for this module cover a few basic topics in computing technology. We'll go over the foundations of computer science, algorithms, memory and data structures, efficiency, software engineering, and computational biology software.
1 hour to complete
6 videos (Total 39 min)
6 videos
Algorithms4m
Memory and Data Structures6m
Efficiency3m
Software Engineering8m
What is Computational Biology Software11m
1 practice exercise
Quiz 3: Computing Technology30m
2 hours to complete
Data Science Technology
In this module on Data Science Technology, we'll be covering quite a lot of information about how to handle the data produced during the sequencing process. We'll cover reproducibility, analysis, statistics, question types, the central dogma of inference, analysis code, testing, prediction, variation, experimental design, confounding, power, sample size, correlation, causation, and degrees of freedom.
2 hours to complete
10 videos (Total 55 min), 2 readings, 2 quizzes
10 videos
What Went Wrong?4m
The Central Dogma of Statistics3m
Data Sharing Plans4m
Getting Help with Statistics2m
Plotting Your Data5m
Sample Size and Variability7m
Statistical Significance6m
Multiple Testing7m
Study Design, Batch Effects, and Confounding7m
2 readings
Course Project Instructions and Reading10m
Post-Course Survey10m
2 practice exercises
Quiz 4: Data Science Technology30m
Course Project30m
Reviews
TOP REVIEWS FROM INTRODUCTION TO GENOMIC TECHNOLOGIES
by SSMay 27, 2020
It was well taught. I liked the fact the two professors focused on two different subjects- biology and statistics portion of this course. The paragraphs written below each video was extremely helpful.
by KKNov 20, 2017
Relatively nice introduction course, contents are maybe rather limited, yet as an instructive course, it does provide a clear overview which correlates well with the required answers for the quizzes!
by GHOct 5, 2019
This course provides a gentle introduction to the concepts and terminology associated with genomics. As someone who never took a biology course in high school or university, this course is perfect.
by NLApr 25, 2020
Great introduction to Genomics. The instructors really laid out the practical terms and gave great resources. Weeks 3 and 4 ramp up in difficulty, so some outside research in statistics is helpful.
About the Genomic Data Science Specialization
With genomics sparks a revolution in medical discoveries, it becomes imperative to be able to better understand the genome, and be able to leverage the data and information from genomic datasets. Genomic Data Science is the field that applies statistics and data science to the genome.
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