About this course: Translational science seeks to speed up the process of moving research discoveries from the laboratory into healthcare practices. Numerous scientific and organizational roadblocks can act as obstacles along the path of translation and ultimately hinder the speed of progress in medical research. The National Center for Advancing Translational Sciences (NCATS) was established by the National Institutes of Health (NIH) to transform and accelerate the translational research process, with the intended result of getting treatments to more patients faster. The field of Translational Science aims to bridge these gaps by: Developing new approaches, technologies, resources and models Demonstrating the usefulness of new approaches, technologies, resources and models Disseminating the resulting data, analyses, and methodologies to the broad scientific community Introduction to Translational Science is an introductory course that provides students with a broad understanding of translational science, the types of research that are conducted under the translational science umbrella, and how this research impacts the public at large.The course will compare and contrast current impediments to clinical research with the potential of translational science and will include selected case studies from the University of Rochester.
Who is this class for: The primary audience for this course will be anyone in the community who has interest in learning more about Translational Science. Members of the media might also benefit from this overview of Translational Science.
Created by: University of Rochester
Taught by: Martin S. Zand, MD, PhD, Professor of Medicine – Nephrology
School of Medicine
| Level | Beginner |
| Commitment | The six lessons will be covered in three weeks and require approximately 2-3 hours per week. |
| Language | English |
| How To Pass | Pass all graded assignments to complete the course. |
| User Ratings |
Syllabus
WEEK 1
Translational Science - The Big Picture and T1 - Translation to Humans
The first lesson in Introduction to Translational Science provides an overview of the basic definitions and key concepts related to clinical and translational science and the CTSA program. Students will learn about the different stages of translational research and the roadblocks that impede progress across the spectrum.The second lesson in Introduction to Translational Science provides an introduction to T1 research which is research that translates findings from basic (laboratory) research to humans through developing treatments and interventions. T1 research is often conducted through observational studies, case studies, proof-of-concept studies, phase I clinical trials, and phase II clinical trials
8 videos, 5 readings
- Video: The Big Picture - Part I (7:41)
- Video: The Big Picture - Part II (9:22)
- Video: The Big Picture - Part III (5:20)
- Video: The Big Picture - Part IV (7:00)
- Reading: NCATS Fact Sheet
- Reading: The Clinical and Translational Science Award (CTSA) Consortium and the Translational Research Model
- Reading: Transforming Translation: Impact of Clinical and Translational Science
- Discussion Prompt: Barriers to Translational Science?
- Video: T1 - Translation to Humans - Introduction (10:48)
- Video: T1 - Translation to Humans Part I (6:59)
- Video: T1 - Translation to Humans Part II (8:37)
- Reading: Translational biomarker discovery in clinical metabolomics: an introductory tutorial
- Reading: The hematopoietic stem cell niche in homeostasis and disease
- Discussion Prompt: Preclinical research?
Graded: Module 1 Quiz
WEEK 2
T2 - Translation to Patients and T3 - Translation to Practice
The third lesson in Introduction to Translational Science provides an introduction to T2 research, which is research that translates findings from T1 research (humans) to patients. T2 research is often conducted through Phase III clinical trials, observational studies, evidence synthesis, and clinical guidelines development.
The fourth lesson in Introduction to Translational Science provides an introduction to T3 research, which is research that translates findings from T2 research (patients) to actual clinical practices. T3 research is often conducted through Phase IV clinical trials, health services research, and clinical outcomes research.
9 videos, 6 readings
- Video: T2 - Translation to Patients - Part I (7:34)
- Video: T2 - Translation to Patients - Part II (6:50)
- Video: T2 - Translation to Patients - Part III (6:50)
- Video: T2 - Translation to Patients - Part IV (9:55)
- Reading: Using Electronically Available Inpatient Hospital Data for Research
- Reading: The mPower study, Parkinson disease mobile data collected using ResearchKit
- Reading: Moving from the Laboratory Bench to Patients’ Bedside: Considerations for Effective Therapy with Stem Cells
- Discussion Prompt: Health-related applications?
- Video: T3 - Translation to Practice - Introduction (8:36)
- Video: T3 - Translation to Practice - Part 1 (6:18)
- Video: T3 - Translation to Practice - Part II (8:22)
- Video: T3 - Translation to Practice - Part III (9:26)
- Reading: Partnering to Reduce Environmental Hazards Through a Community-Based “Healthy Home Museum”:Education for Action
- Reading: Health Services Research: An Evolving Definition of the Field
- Reading: White Paper on CTSA Consortium Role in Facilitating Comparative Effectiveness Research
- Discussion Prompt: Enviornmental concerns in the community?
Graded: Module 2 Quiz
WEEK 3
T4 - Translation to Communities and Participating in Clinical and Translational Research
The fifth lesson of Introduction to Translational Science provides an introduction to T4 research, which is research that translates findings from practices (T3 research) to communities, both domestic and globally. T4 research is often conducted through prevention and outcome studies, mass screening studies, and health policy studies.The sixth lesson of Introduction to Translational Science provides an overview of how interested individuals can participate in clinical and translational research; as an independent research, as a clinical research professional, and as a study volunteer. The final segment of the module demonstrates what a typical study volunteer will encounter if they are selected to participate in a clinical trial.
10 videos, 8 readings
- Video: T4 - Translation to Communities - Part I (9:15)
- Video: T4 - Translation to Communities - Part II (10:09)
- Video: T4 - Translation to Communities - Part III (7:43)
- Video: T4 - Translation to Communities - Part IV (6:58)
- Video: T4 - Translation to Communities - Part V (9:04)
- Reading: Clinical and Translational Science: From Bench-Bedside to Global Village
- Reading: Engaging the Community in the Dissemination, Implementation, and Improvement of Health-Related Research
- Reading: Theoretical Model of Critical issues in Informed Consent in HIV Vaccine Trials
- Reading: Chronic Diseases: The Emerging Pandemic
- Discussion Prompt: Social determinants of health
- Video: Participating in Clinical and Translational Science - Introduction (4:12)
- Video: Participating in Clinical and Translational Science - Part I (5:26)
- Video: Participating in Clinical and Translational Science - Part II (3:51)
- Video: Participating in Clinical and Translational Science - Part III (8:13)
- Reading: Recommendations for Planning Pilot Studies in Clinical and Translational Research
- Reading: Strengthening the Career Development of Clinical Translational Scientist Trainees: A Consensus Statement of the Clinical Translational Science Award (CTSA) Research Education and Career Development Committees
- Reading: Defining Translational Research: Implications for Training
- Reading: Assessing Research Participants’ Perceptions of their Clinical Research Experiences
- Discussion Prompt: Your local academic research center?
Graded: Module 3 Quiz
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Ratings and Reviews
The course shows the variety of how Translational Science is done. I was surprised how it is conducted from several people. The examples made it more clear where
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This was an excellent course that provided a solid foundation for translational medicine and brought us through the T0-T4 translational spectrum with elaborate details and examples at each step. The content was clear, easy to understand, and presented in a engaging way. I especially liked hearing from guest lecturers at the relevant translational stage and enjoyed hearing about their research. The articles were well chosen and related nicely to the videos.