Introduction to Translational Science

University of Rochester

About this Course

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Translational science seeks to speed up the process of moving research discoveries from the laboratory into healthcare practices. Numerous scientific and organizational roadblocks can act as obstacles along the path of translation and ultimately hinder the speed of progress in medical research. The National Center for Advancing Translational Sciences (NCATS) was established by the National Institutes of Health (NIH) to transform and accelerate the translational research process, with the intended result of getting treatments to more patients faster. The field of Translational Science aims to bridge these gaps by:
Developing new approaches, technologies, resources and models 
Demonstrating the usefulness of new approaches, technologies, resources and models 
Disseminating the resulting data, analyses, and methodologies to the broad scientific community 

Introduction to Translational Science is an introductory course that provides students with a broad understanding of translational science, the types of research that are conducted under the translational science umbrella, and how this research impacts the public at large.The course will compare and contrast current impediments to clinical research with the potential of translational science and will include selected case studies from the University of Rochester.

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Beginner Level

Approx. 11 hours to complete

English

Subtitles: English

Instructor

Instructor rating

4.45/5 (12 Ratings)

Martin S. Zand, MD, PhD

Professor of Medicine – Nephrology

School of Medicine

5,455 Learners

1 Course

Shareable Certificate

Earn a Certificate upon completion

100% online

Start instantly and learn at your own schedule.

Flexible deadlines

Reset deadlines in accordance to your schedule.

Beginner Level

Approx. 11 hours to complete

English

Subtitles: English

Offered by

University of Rochester

The University of Rochester is one of the nation's leading private universities. Located in Rochester, N.Y., the University provides exceptional opportunities for interdisciplinary study and close collaboration with faculty through its unique cluster-based curriculum. Its College, School of Arts and Sciences, and Hajim School of Engineering and Applied Sciences are complemented by its Eastman School of Music, Simon School of Business, Warner School of Education, Laboratory for Laser Energetics, School of Medicine and Dentistry, School of Nursing, Eastman Institute for Oral Health, and the Memorial Art Gallery.

Syllabus - What you will learn from this course

Week

Week 1

3 hours to complete

Translational Science - The Big Picture and T1 - Translation to Humans

The first lesson in Introduction to Translational Science provides an overview of the basic definitions and key concepts related to clinical and translational science and the CTSA program. Students will learn about the different stages of translational research and the roadblocks that impede progress across the spectrum.The second lesson in Introduction to Translational Science provides an introduction to T1 research which is research that translates findings from basic (laboratory) research to humans through developing treatments and interventions. T1 research is often conducted through observational studies, case studies, proof-of-concept studies, phase I clinical trials, and phase II clinical trials

3 hours to complete

8 videos (Total 59 min), 5 readings, 1 quiz

8 videos

The Big Picture - Introduction (2:54)2m

The Big Picture - Part I (7:41)7m

The Big Picture - Part II (9:22)9m

The Big Picture - Part III (5:20)5m

The Big Picture - Part IV (7:00)6m

T1 - Translation to Humans - Introduction (10:48)10m

T1 - Translation to Humans Part I (6:59)6m

T1 - Translation to Humans Part II (8:37)8m

5 readings

NCATS Fact Sheet10m

The Clinical and Translational Science Award (CTSA) Consortium and the Translational Research Model15m

Transforming Translation: Impact of Clinical and Translational Science15m

Translational biomarker discovery in clinical metabolomics: an introductory tutorial45m

The hematopoietic stem cell niche in homeostasis and disease15m

1 practice exercise

Module 1 Quiz30m

Week

Week 2

3 hours to complete

T2 - Translation to Patients and T3 - Translation to Practice

The third lesson in Introduction to Translational Science provides an introduction to T2 research, which is research that translates findings from T1 research (humans) to patients. T2 research is often conducted through Phase III clinical trials, observational studies, evidence synthesis, and clinical guidelines development.

3 hours to complete

9 videos (Total 73 min), 6 readings, 1 quiz

9 videos

T2 - Translation to Patients - Introduction (9:18)9m

T2 - Translation to Patients - Part I (7:34)7m

T2 - Translation to Patients - Part II (6:50)6m

T2 - Translation to Patients - Part III (6:50)6m

T2 - Translation to Patients - Part IV (9:55)9m

T3 - Translation to Practice - Introduction (8:36)8m

T3 - Translation to Practice - Part 1 (6:18)6m

T3 - Translation to Practice - Part II (8:22)8m

T3 - Translation to Practice - Part III (9:26)9m

6 readings

Using Electronically Available Inpatient Hospital Data for Research15m

The mPower study, Parkinson disease mobile data collected using ResearchKit15m

Moving from the Laboratory Bench to Patients’ Bedside: Considerations for Effective Therapy with Stem Cells15m

Partnering to Reduce Environmental Hazards Through a Community-Based “Healthy Home Museum”:Education for Action15m

Health Services Research: An Evolving Definition of the Field10m

White Paper on CTSA Consortium Role in Facilitating Comparative Effectiveness Research15m

1 practice exercise

Module 2 Quiz30m

Week

Week 3

4 hours to complete

T4 - Translation to Communities and Participating in Clinical and Translational Research

The fifth lesson of Introduction to Translational Science provides an introduction to T4 research, which is research that translates findings from practices (T3 research) to communities, both domestic and globally. T4 research is often conducted through prevention and outcome studies, mass screening studies, and health policy studies.The sixth lesson of Introduction to Translational Science provides an overview of how interested individuals can participate in clinical and translational research; as an independent research, as a clinical research professional, and as a study volunteer. The final segment of the module demonstrates what a typical study volunteer will encounter if they are selected to participate in a clinical trial.

4 hours to complete

10 videos (Total 74 min), 8 readings, 1 quiz

10 videos

T4 - Translation to Communities - Introduction (9:30)9m

T4 - Translation to Communities - Part I (9:15)9m

T4 - Translation to Communities - Part II (10:09)10m

T4 - Translation to Communities - Part III (7:43)7m

T4 - Translation to Communities - Part IV (6:58)6m

T4 - Translation to Communities - Part V (9:04)9m

Participating in Clinical and Translational Science - Introduction (4:12)4m

Participating in Clinical and Translational Science - Part I (5:26)5m

Participating in Clinical and Translational Science - Part II (3:51)3m

Participating in Clinical and Translational Science - Part III (8:13)8m

8 readings

Clinical and Translational Science: From Bench-Bedside to Global Village10m

Engaging the Community in the Dissemination, Implementation, and Improvement of Health-Related Research10m

Theoretical Model of Critical issues in Informed Consent in HIV Vaccine Trials15m

Chronic Diseases: The Emerging Pandemic5m

Recommendations for Planning Pilot Studies in Clinical and Translational Research10m

Strengthening the Career Development of Clinical Translational Scientist Trainees: A Consensus Statement of the Clinical Translational Science Award (CTSA) Research Education and Career Development Committees10m

Defining Translational Research: Implications for Training15m

Assessing Research Participants’ Perceptions of their Clinical Research Experiences15m

1 practice exercise

Module 3 Quiz30m

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Introduction to Translational Science

Introduction to Translational Science