Johns Hopkins University
Toxicology 21: Scientific Applications
Johns Hopkins University

Toxicology 21: Scientific Applications

Taught in English

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10,555 already enrolled


Gain insight into a topic and learn the fundamentals

Lena Smirnova
Thomas Hartung

Instructors: Lena Smirnova


(80 reviews)

Intermediate level
Some related experience required
95 hours to complete
3 weeks at 31 hours a week
Flexible schedule
Learn at your own pace

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There are 7 modules in this course

This model will give you a broad introduction to the Toxicology 21st century (Tox21c) field and familiarize you with the main document, which summarize the main ideas and principles of Tox21c.

What's included

10 videos3 readings1 quiz1 discussion prompt

This module will discuss how ToxCast and Tox21 technologies can be used in practice. The US EPA Endocrine Disruptor Screening Program will be discussed in detail and we will demonstrate how the ToxCast platform replaced in vivo tiered approaches in EDSP and, thus, acelerate the process of . In the second lesson of this module, the development of in silico models for toxicity testing will be discussed.

What's included

10 videos4 readings1 quiz1 peer review2 discussion prompts

This module will familiarize you with the Human Toxome Project run by Johns Hopkins University in collaboration with several university, industry, and research agencies. Omics technologies, their advantages and disadvantages, as well as concepts of Adverse Outcome Pathways (AOP) and Pathways of Toxicity (PoT) will be discussed.

What's included

10 videos2 readings1 quiz1 discussion prompt

The first lesson in this module will explain the concept of read-across, why it is important for regulatory risk assessment, and how it can be implemented by industry in response to REACH legislation. The organotypic cultures lesson will teach you about existing in vitro cell-based models starting from simple monolayer cultures of cell lines and ending with complex combined organ-on-a-chip and human-on-a-chip approaches.

What's included

18 videos3 readings2 quizzes1 discussion prompt

This module will teach you the role of miRNA and epigenetics in toxicology and environmental health.

What's included

6 videos1 reading1 quiz1 discussion prompt

In this module you will learn about important component of in vitro toxicology such as in vitro to in vivo extrapolation (IVIVE) and physiologically based biokinetic modeling. You will learn why it is important to consider biokinetics in vitro and see some example of biokinetics modeling in vitro. This lesson will also give you a biometry prospective of in vitro toxicology. You will learn which methods can be used to analyze big data.

What's included

8 videos3 readings1 quiz1 peer review

In this lesson you will learn about integrated testing strategies and how they differ from individual tests or test batteries. Also a wrap-up lesson "beyond chemical" will summaries your knowledge from this course and give a out-look for further directions in the field of alternatives to animal testing.

What's included

11 videos2 readings2 quizzes


Instructor ratings
4.7 (29 ratings)
Lena Smirnova
Johns Hopkins University
2 Courses17,331 learners
Thomas Hartung
Johns Hopkins University
2 Courses17,331 learners

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