Back to Finding Hidden Messages in DNA (Bioinformatics I)
University of California San Diego

Finding Hidden Messages in DNA (Bioinformatics I)

Named a top 50 MOOC of all time by Class Central! This course begins a series of classes illustrating the power of computing in modern biology. Please join us on the frontier of bioinformatics to look for hidden messages in DNA without ever needing to put on a lab coat. In the first half of the course, we investigate DNA replication, and ask the question, where in the genome does DNA replication begin? We will see that we can answer this question for many bacteria using only some straightforward algorithms to look for hidden messages in the genome. In the second half of the course, we examine a different biological question, when we ask which DNA patterns play the role of molecular clocks. The cells in your body manage to maintain a circadian rhythm, but how is this achieved on the level of DNA? Once again, we will see that by knowing which hidden messages to look for, we can start to understand the amazingly complex language of DNA. Perhaps surprisingly, we will apply randomized algorithms, which roll dice and flip coins in order to solve problems. Finally, you will get your hands dirty and apply existing software tools to find recurring biological motifs within genes that are responsible for helping Mycobacterium tuberculosis go "dormant" within a host for many years before causing an active infection.

Status: Microbiology
Status: Bioinformatics
IntermediateCourse16 hours

Featured reviews

QL

5.0Reviewed Jul 26, 2017

The algorithms mentioned in this course are explained very well. But still a little bit of programming language is needed. Look forward to the advanced courses.

JN

5.0Reviewed Sep 22, 2020

Please be clear while explaining the course. it not clear what are they trying to explain and it takes a lot time for us to figure it out.

OO

5.0Reviewed Jul 15, 2020

I really enjoyed the course, most especially the code challenges in the honors track. Thanks to the tutors for this wonderful course!

VV

4.0Reviewed Jul 4, 2024

Amazing course. Definitely a steep uphill climb, but designed to make one think deep and understand complex concepts. Worth the effort !

EE

4.0Reviewed Jun 27, 2017

A good course and introduction. Some of the computer graded homework assignments need better explanations for the desired result set, to avoid frustration.

VK

5.0Reviewed Apr 12, 2020

Overall, the course is great. However, in the week 4, the quality of pseudocode is not as good, it is much harder to follow. Would love to have had a more extensive explanation.

SH

5.0Reviewed Apr 6, 2020

Excellent introduction to bioinformatics. They put a lot of heart and thought into the design of the course. I will continue to use the concepts I've learned in and out of bioinformatics.

AC

5.0Reviewed Mar 28, 2019

I feel this was a good introduction to bioinformatics. It can be a little confusing sometimes, but there was nothing I could not figure out in the end

GR

4.0Reviewed Mar 23, 2021

After completing the entire course, I feel like the majority of it was explained well. The assignments are fair and the content is interesting.

AA

5.0Reviewed Apr 29, 2020

Extremely helpful. This course is not limited to teaching us to use Bioinformatic Tools, it also helps us understand deeply the ways in which the tools work.

JL

5.0Reviewed Jul 29, 2018

This course is very very good. Challenging at times. It does not hold your hand at all times and sometimes requires research to solve some of the problems, but I like the community and the approach.

PS

4.0Reviewed Jul 19, 2022

The course has a good material, however I consider is not explained correctly. Sometimes it is very hard to understand each topics and you need some knowleadge related with programming.

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