This course explores the fundamental principles of thermodynamics as applied to gases and chemical reaction via Python programming. It begins with the relationships between pressure, temperature, and volume in gaseous systems, comparing ideal gas behavior with real gas models such as the van der Waals equation, and progresses through the First Law of Thermodynamics, including work, heat, enthalpy, and heat capacity. Building on these foundations, the course examines the thermodynamic criteria for spontaeity and equilibrium through entropy, the Second and Third Laws of Thermodynamics, and Gibbs free energy. Students apply these concepts via Python programming to chemical equilibria, including equilibrium constants and temperature dependence, with a focused case study on the Haber process to connect theory with real-world chemical systems.