This course explores the principles of machine learning through the lens of one of its most powerful and versatile model classes: the artificial neural network. We will cover the fundamental machine learning concepts of modeling, training, and generalization. You will learn how to process the input data with feed-forward operations, how to train a neural network model using gradient-based optimization and the backpropagation algorithm, and how to ensure it performs well on new data using regularization. In the final module, we discuss Bayesian neural networks, learning how to build models that not only make predictions but also quantify their own uncertainty.