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In diesem Kurs gibt es 5 Module
This course describes how viruses interact with their hosts to infect, replicate, spread and cause disease. It looks at what controls the specificity of viruses for different host species and for different tissues within a host, also how this can lead to outbreaks and pandemics. It seeks to show how virus evolution is driven by the pressures to replicate and spread. Finally, it looks at how we can find antivirals and use them to control infections, distinguishing therapeutic approaches to prophylaxis by vaccination.
On successful completion of the course, learners will be able to:
1. Identify key interfaces of virus: host interaction
2. Verify how transmission drives virus pathogenesis and shapes virus evolution
3. Demonstrate an understanding of how virus control with anti-virals differs from protection with vaccines.
This is an intermediate series of courses intended for both clinical and non-clinical scientists who want to update their skills for work in clinical, academic, and pharmaceutical/bioscience industries, and is developed and delivered by experts working on viruses and novel vaccines.
To be successful in this series of courses, you should have basic knowledge in biology, genetics, microbiology or related fields.
Viruses can cause mild, chronic and severe illness and even death. The clinical effects of viruses might occur days or weeks and even months or years after the initial infection, even causing lifelong negative influences on life and livelihood. The impact is experienced by individuals, families, communities, workplaces, healthcare systems, and society. When we have outbreaks, epidemics and even pandemics of virus disease the effects can be devastating. In this module, we will look at viruses and focus on how they cause disease, and what factors affect pathogenesis and virulence.
Das ist alles enthalten
7 Videos4 Lektüren2 Aufgaben1 Diskussionsthema
Infos zu Modulinhalt anzeigen
7 Videos•Insgesamt 48 Minuten
Introduction to ‘What do viruses do and how do we control them?'•2 Minuten
What do we mean by ‘pathogenesis’ and ‘virulence’?•10 Minuten
Why do viruses cause disease?•3 Minuten
How does route of transmission affect pathogenesis?•5 Minuten
How do viruses cause disease?•9 Minuten
Why do diseases differ in severity between viruses and between hosts?•9 Minuten
Why don’t viruses kill us all?•9 Minuten
4 Lektüren•Insgesamt 40 Minuten
Course syllabus•10 Minuten
Introduction to pathogenesis and virulence•10 Minuten
What do viruses do and how do we control them glossary•10 Minuten
Introduction to viruses, disease and transmission•10 Minuten
2 Aufgaben•Insgesamt 40 Minuten
Summative Quiz•30 Minuten
Viruses, disease and transmission•10 Minuten
1 Diskussionsthema•Insgesamt 10 Minuten
How can viruses cause severe disease?•10 Minuten
Virus ‘lifestyles’ – why do some viruses cause short duration diseases and others cause cancer?
Modul 2•2 Stunden abzuschließen
Moduldetails
What are viruses doing inside host cells? How are they making copies of themselves? How are those copies getting out to infect other cells within us? And how are they getting out of us to infect others?
In this module, we will look at the replication strategies of different groups of viruses in humans, known as their ‘lifestyles’.
Das ist alles enthalten
5 Videos3 Lektüren3 Aufgaben1 Diskussionsthema
Infos zu Modulinhalt anzeigen
5 Videos•Insgesamt 47 Minuten
Virus lifestyles•7 Minuten
Acute virus infections•7 Minuten
Chronic virus infections•12 Minuten
Latent virus infections•13 Minuten
Viruses in cancer and progressive diseases•8 Minuten
3 Lektüren•Insgesamt 30 Minuten
Introduction to virus lifestyles•10 Minuten
Introduction to acute, chronic and latent infections•10 Minuten
Introduction to viruses in cancer and chronic diseases•10 Minuten
3 Aufgaben•Insgesamt 50 Minuten
Summative quiz•30 Minuten
Viruses lifestyles and viral infection•10 Minuten
Virus families, their behaviour and links to human cancer•10 Minuten
1 Diskussionsthema•Insgesamt 10 Minuten
Techniques for measuring virus load?•10 Minuten
Tissue tropism and host range – why do viruses infect different animals and cause different diseases
Modul 3•3 Stunden abzuschließen
Moduldetails
Viruses are truly parasitic microorganisms. We have seen repeatedly how receptors, on host cells, and attachment proteins, on viruses, affect which cells a virus can enter. Once inside the cell, viruses still need the cell to supply the energy and all the raw materials they need to replicate themselves, as well as the environment and much of the machinery.
In this module, we will explore the concepts of virus tissue and host range, and explore key questions around how viruses interact with host cells.
Das ist alles enthalten
7 Videos3 Lektüren2 Aufgaben
Infos zu Modulinhalt anzeigen
7 Videos•Insgesamt 87 Minuten
What determines tissue and host range?•7 Minuten
What makes a virus a specialist or a generalist?•9 Minuten
How do receptors influence tissue and host range?•10 Minuten
Interview - Positive and negative host restriction factors•17 Minuten
What intracellular factors affect tissue and host range?•10 Minuten
Interview - The role of latent virus RNAs as immunomodulators and their implication in cancer, and the role of EBV in MS•28 Minuten
How can the virus evolve to change its tissue and host range?•6 Minuten
3 Lektüren•Insgesamt 30 Minuten
Introduction to virus tissue and host range•10 Minuten
Introduction to factors influencing tissue and host range•10 Minuten
Introduction to tissue and host range evolution•10 Minuten
2 Aufgaben•Insgesamt 40 Minuten
Summative Quiz•30 Minuten
Virus tissue and host range•10 Minuten
How and why do outbreaks and pandemics occur, and why do they often emerge from animals?
Modul 4•2 Stunden abzuschließen
Moduldetails
When outbreaks and pandemics start to happen, what do we hear about? It might be the symptoms. It will likely be the number of reported cases or fatalities. It might be what we are advised to do to avoid infection. And we also have a curiosity, or even a need, to find out where this virus came from. And in some cases, a major source of virus outbreaks has been other animals. In this module, we will look at virus threats from animals, known as ‘zoonotic infections’.
Das ist alles enthalten
5 Videos3 Lektüren2 Aufgaben2 Diskussionsthemen
Infos zu Modulinhalt anzeigen
5 Videos•Insgesamt 34 Minuten
Do all zoonotic virus infections lead to epidemics and pandemics?•6 Minuten
Why are we seeing so many emergences of viruses from animals?•6 Minuten
What determines whether an animal virus will become established in humans?•7 Minuten
Why are infections often more severe in their new host?•6 Minuten
Do emerging viruses always evolve to be less severe in the new host?•9 Minuten
3 Lektüren•Insgesamt 30 Minuten
Introduction to how and why outbreaks and pandemics occur•10 Minuten
Introduction to animal viruses in humans•10 Minuten
Introduction to emerging virus evolution and severity•10 Minuten
2 Aufgaben•Insgesamt 40 Minuten
Summative Quiz•30 Minuten
Virus lifestyles•10 Minuten
2 Diskussionsthemen•Insgesamt 20 Minuten
Emerging viruses from zoonotic origins and COVID-19•10 Minuten
Known viruses from zoonotic origins•10 Minuten
How can we prevent and/or control virus infections and outbreaks?
Modul 5•3 Stunden abzuschließen
Moduldetails
Antibiotics have kept us safe from bacterial infections all over the world. In situations and places that would previously have had significant mortality. However, they have their origins in, and deal with very different pathogens to antivirals. Simply because viruses have taken a completely different path and developed an incredibly effective strategy for causing viral infection in their host, making them much more difficult to treat. In this final module, we will look at the whole topic of how we prevent and control virus infections and outbreaks.
Das ist alles enthalten
8 Videos5 Lektüren2 Aufgaben
Infos zu Modulinhalt anzeigen
8 Videos•Insgesamt 70 Minuten
Why are viruses harder to target with therapeutics than bacteria?•7 Minuten
What measures are available to prevent or control virus outbreaks?•8 Minuten
Interview - The role of mass virus diagnostics in outbreak prevention•14 Minuten
How do we decide what antivirals to use, and when?•12 Minuten
How do we handle virus resistance to antivirals?•7 Minuten
Are there new ways we might prevent outbreaks?•11 Minuten
Interview - Going forward with virology research to best prevent and control future outbreaks•9 Minuten
Course Summary•2 Minuten
5 Lektüren•Insgesamt 50 Minuten
Introduction to how we prevent and control virus infections and outbreaks•10 Minuten
Introduction to outbreak prevention and control•10 Minuten
Introduction to which antivirals and their timing•10 Minuten
Introduction to virus resistance to antivirals•10 Minuten
Introduction to pandemic prevention through outbreak responses•10 Minuten
2 Aufgaben•Insgesamt 40 Minuten
Summative Quiz•30 Minuten
What viruses do and how we control them•10 Minuten
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