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Il y a 5 modules dans ce cours
This course describes how viruses interact with their hosts to infect, replicate, spread and cause disease. It looks at what controls the specificity of viruses for different host species and for different tissues within a host, also how this can lead to outbreaks and pandemics. It seeks to show how virus evolution is driven by the pressures to replicate and spread. Finally, it looks at how we can find antivirals and use them to control infections, distinguishing therapeutic approaches to prophylaxis by vaccination.
On successful completion of the course, learners will be able to:
1. Identify key interfaces of virus: host interaction
2. Verify how transmission drives virus pathogenesis and shapes virus evolution
3. Demonstrate an understanding of how virus control with anti-virals differs from protection with vaccines.
This is an intermediate series of courses intended for both clinical and non-clinical scientists who want to update their skills for work in clinical, academic, and pharmaceutical/bioscience industries, and is developed and delivered by experts working on viruses and novel vaccines.
To be successful in this series of courses, you should have basic knowledge in biology, genetics, microbiology or related fields.
Viruses can cause mild, chronic and severe illness and even death. The clinical effects of viruses might occur days or weeks and even months or years after the initial infection, even causing lifelong negative influences on life and livelihood. The impact is experienced by individuals, families, communities, workplaces, healthcare systems, and society. When we have outbreaks, epidemics and even pandemics of virus disease the effects can be devastating. In this module, we will look at viruses and focus on how they cause disease, and what factors affect pathogenesis and virulence.
Inclus
7 vidéos4 lectures2 devoirs1 sujet de discussion
Afficher les informations sur le contenu du module
7 vidéos•Total 48 minutes
Introduction to ‘What do viruses do and how do we control them?'•2 minutes
What do we mean by ‘pathogenesis’ and ‘virulence’?•10 minutes
Why do viruses cause disease?•3 minutes
How does route of transmission affect pathogenesis?•5 minutes
How do viruses cause disease?•9 minutes
Why do diseases differ in severity between viruses and between hosts?•9 minutes
Why don’t viruses kill us all?•9 minutes
4 lectures•Total 40 minutes
Course syllabus•10 minutes
Introduction to pathogenesis and virulence•10 minutes
What do viruses do and how do we control them glossary•10 minutes
Introduction to viruses, disease and transmission•10 minutes
2 devoirs•Total 40 minutes
Summative Quiz•30 minutes
Viruses, disease and transmission•10 minutes
1 sujet de discussion•Total 10 minutes
How can viruses cause severe disease?•10 minutes
Virus ‘lifestyles’ – why do some viruses cause short duration diseases and others cause cancer?
Module 2•2 heures à terminer
Détails du module
What are viruses doing inside host cells? How are they making copies of themselves? How are those copies getting out to infect other cells within us? And how are they getting out of us to infect others?
In this module, we will look at the replication strategies of different groups of viruses in humans, known as their ‘lifestyles’.
Inclus
5 vidéos3 lectures3 devoirs1 sujet de discussion
Afficher les informations sur le contenu du module
5 vidéos•Total 47 minutes
Virus lifestyles•7 minutes
Acute virus infections•7 minutes
Chronic virus infections•12 minutes
Latent virus infections•13 minutes
Viruses in cancer and progressive diseases•8 minutes
3 lectures•Total 30 minutes
Introduction to virus lifestyles•10 minutes
Introduction to acute, chronic and latent infections•10 minutes
Introduction to viruses in cancer and chronic diseases•10 minutes
3 devoirs•Total 50 minutes
Summative quiz•30 minutes
Viruses lifestyles and viral infection•10 minutes
Virus families, their behaviour and links to human cancer•10 minutes
1 sujet de discussion•Total 10 minutes
Techniques for measuring virus load?•10 minutes
Tissue tropism and host range – why do viruses infect different animals and cause different diseases
Module 3•3 heures à terminer
Détails du module
Viruses are truly parasitic microorganisms. We have seen repeatedly how receptors, on host cells, and attachment proteins, on viruses, affect which cells a virus can enter. Once inside the cell, viruses still need the cell to supply the energy and all the raw materials they need to replicate themselves, as well as the environment and much of the machinery.
In this module, we will explore the concepts of virus tissue and host range, and explore key questions around how viruses interact with host cells.
Inclus
7 vidéos3 lectures2 devoirs
Afficher les informations sur le contenu du module
7 vidéos•Total 87 minutes
What determines tissue and host range?•7 minutes
What makes a virus a specialist or a generalist?•9 minutes
How do receptors influence tissue and host range?•10 minutes
Interview - Positive and negative host restriction factors•17 minutes
What intracellular factors affect tissue and host range?•10 minutes
Interview - The role of latent virus RNAs as immunomodulators and their implication in cancer, and the role of EBV in MS•28 minutes
How can the virus evolve to change its tissue and host range?•6 minutes
3 lectures•Total 30 minutes
Introduction to virus tissue and host range•10 minutes
Introduction to factors influencing tissue and host range•10 minutes
Introduction to tissue and host range evolution•10 minutes
2 devoirs•Total 40 minutes
Summative Quiz•30 minutes
Virus tissue and host range•10 minutes
How and why do outbreaks and pandemics occur, and why do they often emerge from animals?
Module 4•2 heures à terminer
Détails du module
When outbreaks and pandemics start to happen, what do we hear about? It might be the symptoms. It will likely be the number of reported cases or fatalities. It might be what we are advised to do to avoid infection. And we also have a curiosity, or even a need, to find out where this virus came from. And in some cases, a major source of virus outbreaks has been other animals. In this module, we will look at virus threats from animals, known as ‘zoonotic infections’.
Inclus
5 vidéos3 lectures2 devoirs2 sujets de discussion
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5 vidéos•Total 34 minutes
Do all zoonotic virus infections lead to epidemics and pandemics?•6 minutes
Why are we seeing so many emergences of viruses from animals?•6 minutes
What determines whether an animal virus will become established in humans?•7 minutes
Why are infections often more severe in their new host?•6 minutes
Do emerging viruses always evolve to be less severe in the new host?•9 minutes
3 lectures•Total 30 minutes
Introduction to how and why outbreaks and pandemics occur•10 minutes
Introduction to animal viruses in humans•10 minutes
Introduction to emerging virus evolution and severity•10 minutes
2 devoirs•Total 40 minutes
Summative Quiz•30 minutes
Virus lifestyles•10 minutes
2 sujets de discussion•Total 20 minutes
Emerging viruses from zoonotic origins and COVID-19•10 minutes
Known viruses from zoonotic origins•10 minutes
How can we prevent and/or control virus infections and outbreaks?
Module 5•3 heures à terminer
Détails du module
Antibiotics have kept us safe from bacterial infections all over the world. In situations and places that would previously have had significant mortality. However, they have their origins in, and deal with very different pathogens to antivirals. Simply because viruses have taken a completely different path and developed an incredibly effective strategy for causing viral infection in their host, making them much more difficult to treat. In this final module, we will look at the whole topic of how we prevent and control virus infections and outbreaks.
Inclus
8 vidéos5 lectures2 devoirs
Afficher les informations sur le contenu du module
8 vidéos•Total 70 minutes
Why are viruses harder to target with therapeutics than bacteria?•7 minutes
What measures are available to prevent or control virus outbreaks?•8 minutes
Interview - The role of mass virus diagnostics in outbreak prevention•14 minutes
How do we decide what antivirals to use, and when?•12 minutes
How do we handle virus resistance to antivirals?•7 minutes
Are there new ways we might prevent outbreaks?•11 minutes
Interview - Going forward with virology research to best prevent and control future outbreaks•9 minutes
Course Summary•2 minutes
5 lectures•Total 50 minutes
Introduction to how we prevent and control virus infections and outbreaks•10 minutes
Introduction to outbreak prevention and control•10 minutes
Introduction to which antivirals and their timing•10 minutes
Introduction to virus resistance to antivirals•10 minutes
Introduction to pandemic prevention through outbreak responses•10 minutes
2 devoirs•Total 40 minutes
Summative Quiz•30 minutes
What viruses do and how we control them•10 minutes
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DC
5·
Révisé le 17 juil. 2025
An excellent course that offered an extremely broad understanding of how we work to control viruses.
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