Precision Medicine

University of Geneva

About this Course

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This course will provide you with the key knowledge and tools to understand the fundamentals and practical implications of precision medicine, its opportunities and challenges. It will address precision-medicine era diagnostics, treatment selection, genetic counseling, public health interventions, and biomedical research. It will also deal with data science and ethical issues.
From genomic analysis and genetic counseling to cancer biomarkers, from risk assessment of chronic diseases to the understanding of gene-environment interactions, from pharmacogenomics to multi-omics data integration, experts will walk you through the many aspects of precision medicine, from the bench to the bedside and to population health.

Designed for students with a bachelor-level training in life sciences, this course will also be useful for professionals who are increasingly expected to deal with precision medicine, including primary care physicians and other first-line healthcare professionals, cancer and non-communicable diseases specialists, public health policy and decision makers, as well as biomedical researchers and drug developers.

Experts from the multiple domains of genetics and genomics, oncology, pharmacology, data sciences, ethics, and biomedical research will provide you with a comprehensive, multi-faceted overview of precision medicine, richly illustrated with practical examples and clinical case studies, and peppered with formative evaluations.

Whether you are interested or intrigued by topics such as “genethics”, the analysis of exome sequencing, precision diabetes management, hereditary cancers, the ongoing revolution of genetic technologies, genome-exposome interactions, the pharmacogenetics of opioids, data deidentification, blockchain-base patient-consent documentation, or proteomics and biomarkers, this course will explain the concepts, offer insights and present concrete examples, thus providing you with an overall understanding of the rapidly evolving field of precision medicine.

Shareable Certificate

Earn a Certificate upon completion

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Flexible deadlines

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Intermediate Level

Approx. 29 hours to complete

English

Subtitles: French, Portuguese (European), Russian, English, Spanish

Instructors

Shareable Certificate

Earn a Certificate upon completion

100% online

Start instantly and learn at your own schedule.

Flexible deadlines

Reset deadlines in accordance to your schedule.

Intermediate Level

Approx. 29 hours to complete

English

Subtitles: French, Portuguese (European), Russian, English, Spanish

Offered by

University of Geneva

Founded in 1559, the University of Geneva (UNIGE) is one of Europe's leading universities. Devoted to research, education and dialogue, the UNIGE shares the international calling of its host city, Geneva, a centre of international and multicultural activities with a venerable cosmopolitan tradition.

Syllabus - What you will learn from this course

Week

Week 1

4 hours to complete

Monogenic Diseases

4 hours to complete

12 videos (Total 55 min), 4 readings, 6 quizzes

12 videos

Trailer1m

Welcome to the course3m

Introduction to the module2m

Human genome variabilty and phenotype consequences 11m

Human genome variability and phenotype consequences 24m

Medical consultation (part 1)8m

Exome sequencing analysis9m

What are the options? discussion between the physician and the biologist4m

Medical consultation (part 2)2m

Rare genetic disorder and precision medicine7m

Ethical, Legal and Social Implications (ELSI)6m

Conclusion1m

4 readings

How assessments work10m

Syllabus10m

List of Teachers10m

Bibliographic References10m

6 practice exercises

Human genome variability and phenotype consequences30m

Medical consultation part 130m

Exome sequencing analysis30m

Rare genetic disorder and precision medicine30m

Ethical, Legal and Social Implications (ELSI)30m

Monogenic disease22m

Week

Week 2

3 hours to complete

Complex Diseases

3 hours to complete

10 videos (Total 43 min)

10 videos

Introduction1m

Genetics of complex disorders6m

Environmental determinant7m

Diabetes management today2m

Diabetes risk assessment part 110m

The key points - answers to the discussion by the expert (part 1)2m

Precision approaches in diabetes55s

Diabetes risk assessment (part 2)6m

The key points - answers to the discussion by the expert (part 2)2m

Conclusion2m

5 practice exercises

Genetics of complex disorders30m

Environmental determinants30m

How to evaluate the disease risk (part 1)30m

How to evaluate the disease risk (part 2)30m

Complex disease20m

Week

Week 3

3 hours to complete

Cancer

3 hours to complete

18 videos (Total 116 min), 1 reading, 17 quizzes

18 videos

Somatic mutation theory of cancer4m

Synthetic lethality and oncogene addiction5m

Clinically-orientated analysis6m

Introduction to clinical ethics9m

Objectives of precision oncology3m

Tumor classification4m

What is a biomarker?6m

Somatic bioinformatics pipelines9m

Molecular tumor board5m

Ethical and societal implications9m

Sporadic, familial and hereditary cancer5m

Family history in oncology4m

Genetic counselling in oncology10m

Main hereditary cancer syndromes9m

Case study 1 - part 15m

Case study 1 - part 26m

Case study 2 - part 15m

Case study 2 - part 23m

1 reading

Week 4

4 hours to complete

Health and Prevention

4 hours to complete

13 videos (Total 66 min), 1 reading, 7 quizzes

13 videos

Introduction to the module1m

The Revolution of Genetic Technologies7m

Main Opportunities of Genomics1m

Genomics and Complex Chronic Diseases9m

The Revolution of Environmental Technologies7m

Genome-Exposome Interaction2m

Big Data6m

Validity and Massive Information4m

Restitution, Unintended Findings and Actionable Variants2m

Patients' Willingness to Discuss their Genomic Information2m

Evidence-Based Precision Medicine2m

Conclusion1m

New Technologies and Personalized Health: Opportunities and Challenges16m

1 reading

Tyrell and all.10m

7 practice exercises

Testing the opportunities discussed

Testing the illustration discussed30m

Testing the concept of behaviome

Testing the understanding of the Tyrell and all. results30m

Big Data30m

Testing challenges of translating genomics into clinical care30m

Health and prevention22m

Week

Week 5

9 hours to complete

Pharmacogenomics and Drug Development

9 hours to complete

17 videos (Total 110 min), 4 readings, 16 quizzes

17 videos

Introduction to the module1m

Variability in drug response4m

Drug metabolism7m

Role of Transporters in Drug Disposition5m

Case - Pharmacogenomics of Statins7m

Other Cardiovascular Case Studies6m

Pharmacogenomics of opioids7m

Tools for clinicians and patients3m

Current Methods to Identify Pharmacogenomics Variants7m

Phenotyping in the lab5m

Drug development 19m

Drug development 29m

Pharmacovigilance9m

Pharmacoeconomics and pharmacogenomics9m

Citizen Centered Consent7m

Data deidentification5m

Conclusion and Future Perspectives1m

4 readings

Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism10m

Table of Pharmacogenetic Associations10m

Case study: antiaggregant and HIV10m

Case Study: the example of oxycodone10m

16 practice exercises

Variability in drug response30m

Drug metabolism30m

Role of Transporters in Drug Disposition30m

Pharmacogenomics of statins30m

Other cardiovascular diseases30m

Pharmacogenomics of opioids30m

Tools of clinicians and patients30m

Current Methods to Identify Pharmacogenomics Variants30m

Phenotyping in the lab30m

Drug development 130m

Drug development 230m

Pharmacovigilance30m

Pharmacoeconomics and pharmacogenomics

Citizen Centered Consent

Data Deidentification

Evaluation of the module28m

Week

Week 6

5 hours to complete

Research

5 hours to complete

10 videos (Total 59 min), 2 readings, 8 quizzes

10 videos

Introduction to the module1m

First Steps of a Research Project6m

Sample Collection, Biobanking and Data Generation/Recording6m

Data Quality Control and Data Analysis8m

Data dissemination, databases and publication8m

Explanations by the expert8m

Explanation by the expert: patient stratification in traumatic brain injury7m

Explanations by the expert: Steroid Signatures in Toxicology8m

Conclusion of the module2m

Conclusion of the course in Precision Medicine1m

2 readings

Estimating the causal tissues for complex traits and diseases10m

Abstract section of the article10m

8 practice exercises

First steps of a research project30m

Sample collection, biobanking and data generation/recording30m

On Data videos above (2)30m

Questions on published article30m

Questions on abstract - please read abstract before answering30m

Patient stratification in traumatic brain surgery30m

Steroid signatures in toxicology30m

Research14m

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Precision Medicine