This course will provide you with the key knowledge and tools to understand the fundamentals and practical implications of precision medicine, its opportunities and challenges. It will address precision-medicine era diagnostics, treatment selection, genetic counseling, public health interventions, and biomedical research. It will also deal with data science and ethical issues.
From genomic analysis and genetic counseling to cancer biomarkers, from risk assessment of chronic diseases to the understanding of gene-environment interactions, from pharmacogenomics to multi-omics data integration, experts will walk you through the many aspects of precision medicine, from the bench to the bedside and to population health.
Designed for students with a bachelor-level training in life sciences, this course will also be useful for professionals who are increasingly expected to deal with precision medicine, including primary care physicians and other first-line healthcare professionals, cancer and non-communicable diseases specialists, public health policy and decision makers, as well as biomedical researchers and drug developers.
Experts from the multiple domains of genetics and genomics, oncology, pharmacology, data sciences, ethics, and biomedical research will provide you with a comprehensive, multi-faceted overview of precision medicine, richly illustrated with practical examples and clinical case studies, and peppered with formative evaluations.
Whether you are interested or intrigued by topics such as “genethics”, the analysis of exome sequencing, precision diabetes management, hereditary cancers, the ongoing revolution of genetic technologies, genome-exposome interactions, the pharmacogenetics of opioids, data deidentification, blockchain-base patient-consent documentation, or proteomics and biomarkers, this course will explain the concepts, offer insights and present concrete examples, thus providing you with an overall understanding of the rapidly evolving field of precision medicine.
- update -
The contents of this course have been updated and important corrections have been implemented thanks to learners' feedback. Many thanks to them!
What's included
12 videos5 readings6 assignments
Show info about module content
12 videos•Total 55 minutes
Trailer•2 minutes
Welcome to the course•3 minutes
Introduction to the module•3 minutes
Human genome variabilty and phenotype consequences 1•1 minute
Human genome variability and phenotype consequences 2•4 minutes
Medical consultation (part 1)•9 minutes
Exome sequencing analysis•9 minutes
What are the options? discussion between the physician and the biologist•5 minutes
Medical consultation (part 2)•3 minutes
Rare genetic disorder and precision medicine•8 minutes
Ethical, Legal and Social Implications (ELSI)•6 minutes
Conclusion•2 minutes
5 readings•Total 50 minutes
📢 Important preliminary information: Evaluations and subtitles•10 minutes
Syllabus•10 minutes
List of Teachers•10 minutes
Bibliographic References•10 minutes
📢 Important preliminary information: Evaluations and subtitles•10 minutes
6 assignments•Total 172 minutes
Human genome variability and phenotype consequences•30 minutes
Medical consultation part 1•30 minutes
Exome sequencing analysis•30 minutes
Rare genetic disorder and precision medicine•30 minutes
Ethical, Legal and Social Implications (ELSI)•30 minutes
Monogenic disease•22 minutes
Complex Diseases
Module 2•3 hours to complete
Module details
What's included
10 videos5 assignments2 discussion prompts
Show info about module content
10 videos•Total 43 minutes
Introduction•2 minutes
Genetics of complex disorders•7 minutes
Environmental determinant•7 minutes
Diabetes management today•3 minutes
Diabetes risk assessment part 1•10 minutes
The key points - answers to the discussion by the expert (part 1)•3 minutes
Precision approaches in diabetes•1 minute
Diabetes risk assessment (part 2)•6 minutes
The key points - answers to the discussion by the expert (part 2)•3 minutes
Conclusion•2 minutes
5 assignments•Total 140 minutes
Genetics of complex disorders•30 minutes
Environmental determinants•30 minutes
How to evaluate the disease risk (part 1)•30 minutes
How to evaluate the disease risk (part 2)•30 minutes
Complex disease•20 minutes
2 discussion prompts•Total 20 minutes
Diabetes management today•10 minutes
Precision approches in diabetes•10 minutes
Cancer
Module 3•3 hours to complete
Module details
What's included
18 videos1 reading17 assignments
Show info about module content
18 videos•Total 116 minutes
Somatic mutation theory of cancer•5 minutes
Synthetic lethality and oncogene addiction•5 minutes
Clinically-orientated analysis•7 minutes
Introduction to clinical ethics•9 minutes
Objectives of precision oncology•4 minutes
Tumor classification•4 minutes
What is a biomarker?•7 minutes
Somatic bioinformatics pipelines•10 minutes
Molecular tumor board•6 minutes
Ethical and societal implications•10 minutes
Sporadic, familial and hereditary cancer•5 minutes
Family history in oncology•5 minutes
Genetic counselling in oncology•10 minutes
Main hereditary cancer syndromes•9 minutes
Case study 1 - part 1•5 minutes
Case study 1 - part 2•7 minutes
Case study 2 - part 1•5 minutes
Case study 2 - part 2•4 minutes
1 reading•Total 10 minutes
Further reading•10 minutes
17 assignments•Total 68 minutes
Sommatic mutation theory of cancer•0 minutes
Synthetic lethality and oncogene addiction•0 minutes
Introduction to clinical ethics•0 minutes
Objectives of precision oncology•0 minutes
Tumor classification•0 minutes
What is a biomarker?•0 minutes
Somatic bioinformatics pipeline•30 minutes
Molecular tumor board•0 minutes
Ethical and societal implications•0 minutes
Sporadic, familial and hereditary cancer•0 minutes
Family history in oncology•0 minutes
Genetic counselling in oncology•0 minutes
Main hereditary cancer syndromes•2 minutes
Case Study 1 - part 1•0 minutes
Case Study 1 - part 2•0 minutes
Case Study 2 - part 1•0 minutes
Cancer•36 minutes
Health and Prevention
Module 4•4 hours to complete
Module details
What's included
13 videos1 reading7 assignments
Show info about module content
13 videos•Total 66 minutes
Introduction to the module•1 minute
The Revolution of Genetic Technologies•8 minutes
Main Opportunities of Genomics•1 minute
Genomics and Complex Chronic Diseases•9 minutes
The Revolution of Environmental Technologies•8 minutes
Genome-Exposome Interaction•2 minutes
Big Data•7 minutes
Validity and Massive Information•4 minutes
Restitution, Unintended Findings and Actionable Variants•3 minutes
Patients' Willingness to Discuss their Genomic Information•2 minutes
Evidence-Based Precision Medicine•3 minutes
Conclusion•2 minutes
New Technologies and Personalized Health: Opportunities and Challenges•16 minutes
1 reading•Total 10 minutes
Tyrell and all.•10 minutes
7 assignments•Total 142 minutes
Testing the opportunities discussed•0 minutes
Testing the illustration discussed•30 minutes
Testing the concept of behaviome•0 minutes
Testing the understanding of the Tyrell and all. results•30 minutes
Big Data•30 minutes
Testing challenges of translating genomics into clinical care•30 minutes
Health and prevention•22 minutes
Pharmacogenomics and Drug Development
Module 5•9 hours to complete
Module details
What's included
17 videos4 readings16 assignments
Show info about module content
17 videos•Total 107 minutes
Introduction to the module•2 minutes
Variability in drug response•4 minutes
Drug metabolism•7 minutes
Role of Transporters in Drug Disposition•6 minutes
Case - Pharmacogenomics of Statins•8 minutes
Other Cardiovascular Case Studies•7 minutes
Pharmacogenomics of opioids•7 minutes
Tools for clinicians and patients•4 minutes
Current Methods to Identify Pharmacogenomics Variants•7 minutes
Phenotyping in the lab•6 minutes
Drug development 1•9 minutes
Drug development 2•9 minutes
Pharmacovigilance•9 minutes
Pharmacoeconomics of pharmacogenomics•6 minutes
Citizen Centered Consent•8 minutes
Data deidentification•5 minutes
Conclusion and Future Perspectives•2 minutes
4 readings•Total 40 minutes
Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism•10 minutes
Table of Pharmacogenetic Associations•10 minutes
Case study: antiaggregant and HIV•10 minutes
Case Study: the example of oxycodone•10 minutes
16 assignments•Total 388 minutes
Variability in drug response•30 minutes
Drug metabolism•30 minutes
Role of Transporters in Drug Disposition•30 minutes
Pharmacogenomics of statins•30 minutes
Other cardiovascular diseases•30 minutes
Pharmacogenomics of opioids•30 minutes
Tools of clinicians and patients•30 minutes
Current Methods to Identify Pharmacogenomics Variants•30 minutes
Phenotyping in the lab•30 minutes
Drug development 1•30 minutes
Drug development 2•30 minutes
Pharmacovigilance•30 minutes
Pharmacoeconomics and pharmacogenomics•0 minutes
Citizen Centered Consent•0 minutes
Data Deidentification•0 minutes
Pharmacogenomics and Drug Development•28 minutes
Research
Module 6•5 hours to complete
Module details
What's included
10 videos2 readings8 assignments
Show info about module content
10 videos•Total 59 minutes
Introduction to the module•2 minutes
First Steps of a Research Project•7 minutes
Sample Collection, Biobanking and Data Generation/Recording•6 minutes
Data Quality Control and Data Analysis•8 minutes
Data dissemination, databases and publication•9 minutes
Explanations by the expert•8 minutes
Explanation by the expert: patient stratification in traumatic brain injury•7 minutes
Explanations by the expert: Steroid Signatures in Toxicology•9 minutes
Conclusion of the module•2 minutes
Conclusion of the course in Precision Medicine•1 minute
2 readings•Total 20 minutes
Estimating the causal tissues for complex traits and diseases•10 minutes
Abstract section of the article•10 minutes
8 assignments•Total 204 minutes
First steps of a research project•30 minutes
Sample collection, biobanking and data generation/recording•30 minutes
On Data videos above (2)•30 minutes
Questions on published article•10 minutes
Questions on abstract•30 minutes
Patient stratification in traumatic brain injury•30 minutes
Steroid signatures in toxicology•30 minutes
Research•14 minutes
Instructors
Instructor ratings
Instructor ratings
We asked all learners to give feedback on our instructors based on the quality of their teaching style.
Founded in 1559, the University of Geneva (UNIGE) is one of Europe's leading universities. Devoted to research, education and dialogue, the UNIGE shares the international calling of its host city, Geneva, a centre of international and multicultural activities with a venerable cosmopolitan tradition.
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R
RH
5·
Reviewed on Nov 24, 2022
a detailed and didactic course that opens horizons for healthcare professionals.
A
AH
4·
Reviewed on May 2, 2023
It's a very comprehensive course.
thank you to all the instructors and participants involved in making of this course.
M
MQ
5·
Reviewed on May 21, 2025
The course material and videos were very informative and helped me in developing new insights in the field
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