About this Course
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Approx. 39 hours to complete

Suggested: 7 hours/week...

Chinese (Simplified)

Subtitles: Chinese (Simplified)

100% online

Start instantly and learn at your own schedule.

Flexible deadlines

Reset deadlines in accordance to your schedule.

Approx. 39 hours to complete

Suggested: 7 hours/week...

Chinese (Simplified)

Subtitles: Chinese (Simplified)

Syllabus - What you will learn from this course

Week
1
2 hours to complete

欢迎进入结构生物化学世界(Welcome to the World of Structural Biochemistry)

3 videos (Total 119 min), 1 reading
3 videos
生物化学学习方法系列159m
生物化学学习方法系列257m
1 reading
结构生物化学学习方法10m
Week
2
13 hours to complete

第一章 蛋白质的结构与功能(Chapter 1 Structure and Function of Proteins)

44 videos (Total 230 min), 45 readings, 1 quiz
44 videos
蛋白质氨基酸与非蛋白质氨基酸( Proteinogenic AA & non-protenogenic AA)8m
疏水氨基酸与亲水氨基酸(Hydrophobic & Hydrophilic AAs)7m
必需氨基酸与非必需氨基酸(Essential & Non-essential AAs)3m
氨基酸的英文缩写(Abbreviations for 22 amino acids)5m
氨基酸的缩合反应(AA Condensation reaction)1m
氨基酸的手性(Chirality of Amino Acids)11m
氨基酸的两性解离与等电点(Acid & base dissociation of amino acids and pI)12m
茚三酮反应(Reaction with Ninhydrin)3m
Sanger反应(Reaction with DNFB)2m
Edman反应(Reaction with PITC)2m
蛋白质(Proteins)4m
蛋白质的一级结构(Primary Structure of Proteins)6m
肽键(Peptide bonds)4m
蛋白质的二级结构(Secondary Structure of Proteins)2m
α螺旋(The Alpha Helix)5m
β折叠(The Beta-Pleated Sheet)5m
β转角(The Beta Turn)3m
β突起(The Beta Bulge)1m
蛋白质的三级结构(Tertiary structure of Proteins)5m
疏水键(Hydrophobic interactions)3m
模体(Motif)5m
结构域(Domain)6m
蛋白质的四级结构(Quaternary Structure of Proteins)4m
蛋白质的折叠(Protein folding)4m
天然无折叠蛋白(Natively Unfolded Proteins)4m
Anfinsen实验(Anfinsen’s Experiment)4m
分子伴侣( Molecular Chaperone)6m
蛋白质二硫化物异构酶(Protein disulfide isomerase)4m
脯氨酰肽酰顺反异构酶(Peptidylprolyl cis-trans isomerase)2m
朊病毒(Prions)5m
蛋白质组(Proteome)5m
Functions of Proteins6m
兼职蛋白(Moonlighting Proteins)3m
蛋白质结构与功能之间的关系(Structure and function relationships of proteins)6m
α角蛋白(Alpha Keratin)3m
β角蛋白(Beta Keratin)2m
胶原蛋白(Collagen)5m
肌红蛋白与血红蛋白(Myoglobin & Hemoglobin)12m
正协同效应(1.40 Positive Cooperativity)9m
波尔效应(Bohr Effect)4m
别构效应(Allosteric effect)4m
HbS5m
HbF3m
45 readings
氨基酸(Amino acids)10m
蛋白质氨基酸与非蛋白质氨基酸(Proteinogenic AA & non-protenogenic AA)10m
疏水氨基酸与亲水氨基酸(Hydrophobic & Hydrophilic AAs)10m
必需氨基酸与非必需氨基酸(Essential & Non-essential AAs)10m
氨基酸的英文缩写(Abbreviations for 22 amino acids)10m
氨基酸的缩合反应(AA Condensation reaction)10m
氨基酸的手性(Chirality of Amino Acids)10m
氨基酸的两性解离与等电点(Acid & base dissociation of amino acids and pI)10m
茚三酮反应(Reaction with Ninhydrin)10m
Sanger反应(Reaction with DNFB)10m
Edman反应(Reaction with PITC)10m
蛋白质(Proteins)10m
蛋白质的一级结构(Primary Structure of Proteins)10m
肽键(Peptide bonds)10m
蛋白质的二级结构(Secondary Structure of Proteins)10m
 α螺旋(The Alpha Helix)10m
β折叠(The Beta-Pleated Sheet)10m
β转角(The Beta Turn)10m
β突起(The Beta Bulge)10m
蛋白质的三级结构(Tertiary Structure of Proteins)10m
 疏水键(Hydrophobic interactions)10m
模体(Motif)10m
结构域(Domain)10m
蛋白质的四级结构(Quaternary Structure of Proteins)10m
蛋白质的折叠(Protein folding)10m
天然无折叠蛋白(Natively Unfolded Proteins)10m
 Anfinsen实验(Anfinsen’s Experiment)10m
分子伴侣(Molecular Chaperone)10m
 蛋白质二硫化物异构酶(Protein Disulfide Isomerase)10m
脯氨酰肽酰顺反异构酶(Peptidylprolyl cis-trans isomerase)10m
朊病毒(Prions)10m
蛋白质组(Proteome)10m
蛋白质的功能(Functions of Proteins)10m
 兼职蛋白(Moonlighting Proteins)10m
蛋白质结构与功能之间的关系(Structure and function relationships of proteins)10m
α角蛋白(Alpha Keratin)10m
β角蛋白(Beta Keratin)10m
胶原蛋白(Collagen)10m
肌红蛋白与血红蛋白(Myoglobin & Hemoglobin)10m
正协同效应(Positive Cooperativity)10m
波尔效应(Bohr Effect)10m
别构效应(Allosteric effect)10m
HbS10m
HbF10m
参考文献和网址(References and Websites)10m
1 practice exercise
第一章 蛋白质的结构与功能(Chapter 1 Structure and Function of Proteins)1h 10m
Week
3
5 hours to complete

第二章 核酸的结构与功能(Chapter 2 Structure and Function of Nucleic Acids)

17 videos (Total 107 min), 18 readings, 1 quiz
17 videos
互变异构(Keto-enol tautomerism)2m
核苷(Nucleosides)6m
核苷酸(Nucleotides)4m
核酸(Nucleic Acids)9m
多种多样的RNA(Versatile RNAs)9m
核酸的一级结构(Primary Structure of Nucleic Acids)2m
B-DNA11m
A-DNA4m
Z-DNA5m
几种DNA非常规的二级结构(Other forms of secondary structure of DNA)14m
RNA二级结构(Secondary Structure of RNA)6m
DNA三级结构(Tertiary Structure of DNA)5m
RNA三级结构(Tertiary Structure of RNA)6m
核糖核酸蛋白复合物(RNA-Protein Complex)4m
核小体(Nucleosome)5m
RNA世界(The RNA world hypothesis)4m
18 readings
碱基(Bases)10m
互变异构(Keto-enol tautomerism)10m
核苷(Nucleosides)10m
核苷酸(Nucleotides)10m
核酸(Nucleic Acids)10m
多种多样的RNA(Versatile RNAs)10m
核酸的一级结构(Primary Structure of Nucleic Acids)10m
B-DNA10m
A-DNA10m
Z-DNA10m
几种DNA的非常规的二级结构(Other forms of secondary structure of DNA)10m
RNA二级结构(Secondary Structure of RNA)10m
DNA三级结构(Tertiary Structure of DNA)10m
RNA三级结构(Tertiary Structure of RNA)10m
核糖核酸蛋白复合物(RNA-Protein Complex)10m
核小体(Nucleosome)10m
RNA世界(The RNA world)10m
参考文献和网址(References and Websites)10m
1 practice exercise
第二章 核酸的结构与功能(Chapter 2 Structure and Function of Nucleic Acids)40m
Week
4
4 hours to complete

第三章 蛋白质和核酸的性质(Chapter 3 Properties of Proteins and Nucleic Acids)

11 videos (Total 61 min), 12 readings, 1 quiz
11 videos
沉淀(Precipitation)6m
两性解离(Acid & base dissociation and pI)4m
变性(Denaturation)13m
复性(Renaturation)3m
Tm4m
水解(Hydrolysis)8m
蛋白质的颜色反应(Protein coloring reaction)2m
电泳(Electrophoresis)4m
层析(Chromatography)5m
透析与超滤(Dialysis and Ultrafiltration)2m
12 readings
紫外吸收(UV absorption)10m
沉淀(Precipitation)10m
两性解离(Acid & base dissociation and pI)10m
 变性(Denaturation)10m
复性(Renaturation)10m
Tm10m
 水解(Hydrolysis)10m
蛋白质的颜色反应(Protein coloring reaction)10m
电泳(Electrophoresis)10m
层析(Chromatography)10m
透析与超滤(Dialysis and Ultrafiltration)10m
参考文献和网址(References and Websites)10m
1 practice exercise
第三章 蛋白质和核酸的性质(Chapter 3 Properties of Proteins and Nucleic Acids)30m

Instructor

Avatar

杨荣武

教授
生命科学学院

About Nanjing University

Nanjing University (NJU) is committed to excellence in teaching and research. Located on the prosperous eastern coast of China, NJU provides a dynamic environment that nurtures learning, creativity, and discovery on one of the most beautiful campuses in the country. Taking NJU's university offerings on Coursera will be a rewarding experience for learners from every corner of the world....

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