Introduction to Genetics and Evolution is a college-level class being offered simultaneously to new students at Duke University. The course gives interested people a very basic overview of some principles behind these very fundamental areas of biology. We often hear about new "genome sequences," commercial kits that can tell you about your ancestry (including pre-human) from your DNA or disease predispositions, debates about the truth of evolution, why animals behave the way they do, and how people found "genetic evidence for natural selection." This course provides the basic biology you need to understand all of these issues better, tries to clarify some misconceptions, and tries to prepare students for future, more advanced coursework in Biology (and especially evolutionary genetics). No prior coursework is assumed.
General introduction to this MOOC, including coverage and expectations.
What's included
3 readings
Show info about module content
3 readings•Total 30 minutes
Welcome to the Course•10 minutes
Course App and Readings•10 minutes
Report a problem with the course•10 minutes
Evidence for Evolution
Module 2•2 hours to complete
Module details
This module discusses the definition of the word "evolution" in a biological context, evidence for the truth of evolution and common ancestry of species, and public thoughts and misconceptions about biological evolution. This module is optional and will not be included in the course assessments. There are not class discussion forums for this section, as we feel such discussion can happen on other, non-course-related, sites on this topic (of which there are a great many on the internet).
What's included
5 videos1 reading
Show info about module content
5 videos•Total 81 minutes
What is Evolution? (G)•8 minutes
Basic Principles and Evidence for Evolution (G)•17 minutes
Acceptance of Evolution (G)•13 minutes
Responding to Criticisms of Evolutionary Theory (G)•12 minutes
Interview with Jerry Coyne (G)•30 minutes
1 reading•Total 10 minutes
Supplemental Materials, Evidence for Evolution•10 minutes
Genetics I
Module 3•2 hours to complete
Module details
An introduction to basic transmission genetics and inheritance. This module reflects what is often covered in high school biology courses in the USA.
What's included
6 videos1 reading2 assignments
Show info about module content
6 videos•Total 74 minutes
Introduction to Genetics (G)•10 minutes
Inheritance (G)•11 minutes
Genetic Scales (S)•12 minutes
Mitosis, Meiosis, and Ploidy (S)•8 minutes
Basic Single-Gene Inheritance (G)•16 minutes
X-Linked Inheritance and Independent Assortment (S)•17 minutes
1 reading•Total 10 minutes
Supplemental Materials, Genetics I•10 minutes
2 assignments•Total 60 minutes
Genetics I Quiz•30 minutes
Genetics Problem Set 1•30 minutes
Genetics II
Module 4•3 hours to complete
Module details
This module delves somewhat more deeply into genetics and specifically the concept of "recombination." It begins to discuss how recombination is leveraged in classic genetic works as well as mapping simple genetic traits using crosses or data from natural populations.
What's included
7 videos1 reading2 assignments
Show info about module content
7 videos•Total 97 minutes
Recombination (G)•15 minutes
Calculation of Recombination Distance (S)•16 minutes
Generating a Gene Map (S)•12 minutes
Bonus Video: A More Challenging Problem (S)•10 minutes
Genetic Mapping (S)•12 minutes
Mapping Traits Relative to Markers in a Cross (S)•11 minutes
Mapping Traits Relative to Markers in a Population (S)•22 minutes
1 reading•Total 10 minutes
Supplemental Materials, Genetics II•10 minutes
2 assignments•Total 60 minutes
Genetics II Quiz•30 minutes
Genetics Problem Set 2•30 minutes
Genetics III
Module 5•2 hours to complete
Module details
This module delves even more deeply into the complexities of the genetics underlying traits,the origin of genetic variation, and how "complex" traits (ones controlled by multiple genes) are studied genetically.
What's included
6 videos1 reading2 assignments
Show info about module content
6 videos•Total 75 minutes
Origin of Genetic Variation (G)•12 minutes
Shortcomings of the Single Gene Model (G)•20 minutes
Mutation Rates (S)•10 minutes
Mapping Complex Traits (S)•12 minutes
Complex Traits in Crosses (S)•9 minutes
Genome-wide Association Studies (S)•12 minutes
1 reading•Total 10 minutes
Supplemental Materials, Genetics III•10 minutes
2 assignments•Total 60 minutes
Genetics III Quiz•30 minutes
Genetics Problem Set 3•30 minutes
Heritability and Population Growth
Module 6•2 hours to complete
Module details
This module begins the transition to evolutionary genetics by looking at the relative contributions of genetics and environment to traits, and also introduces how population growth is studied.
What's included
6 videos1 reading2 assignments
Show info about module content
6 videos•Total 74 minutes
Contribution of Genes vs. Environment I (G, S)•17 minutes
Contribution of Genes vs. Environment II (S)•14 minutes
Contribution of Genes vs. Environment III (S)•7 minutes
Breeder's Equation (S)•10 minutes
Population Growth (S)•15 minutes
Carrying Capacity (S)•11 minutes
1 reading•Total 10 minutes
Supplemental Materials, Heritability and Population Growth•10 minutes
2 assignments•Total 60 minutes
Heritability Quiz•30 minutes
Heritability Problem Set•30 minutes
Population Genetics I
Module 7•2 hours to complete
Module details
Rather than looking at individuals, this module discusses how multiple individuals from natural populations can be studied genetically to begin to understand the evolutionary forces acting upon the populations.
What's included
6 videos1 reading2 assignments
Show info about module content
6 videos•Total 69 minutes
Allele and Genotype Frequencies (S)•9 minutes
Hardy-Weinberg Equilibrium (S)•12 minutes
Deviation from Hardy-Weinberg Equilibrium (S)•13 minutes
Differences Between Populations: Origins and Quantification (S)•15 minutes
Differences Between Populations: Effects of Gene Flow (S)•8 minutes
Inbreeding (S)•13 minutes
1 reading•Total 10 minutes
Supplemental Materials, Population Genetics I•10 minutes
2 assignments•Total 60 minutes
Population Genetics Quiz•30 minutes
Population Genetics Problem Set 1•30 minutes
Population Genetics II
Module 8•3 hours to complete
Module details
This module extends the previous one to specifically examine the effects of natural selection and genetic drift on genetic variation in natural populations.
What's included
7 videos1 reading2 assignments
Show info about module content
7 videos•Total 103 minutes
Natural Selection Fundamentals (S)•18 minutes
Types at Single Loci (S)•22 minutes
Types Acting on Traits (S)•11 minutes
Genetic Drift and Sampling Error (S)•11 minutes
Sampling Error over Many Generations (S)•14 minutes
Case Studies and Examples (G)•15 minutes
Rate of Neutral Molecular Evolution (S)•12 minutes
1 reading•Total 10 minutes
Supplemental Materials, Population Genetics II•10 minutes
2 assignments•Total 60 minutes
Population Genetics II Quiz•30 minutes
Population Genetics Problem Set 2•30 minutes
Molecular Evolution
Module 9•2 hours to complete
Module details
This advanced module explains why sexual reproduction (involving recombination) is evolutionarily advantageous, and discusses how the analysis of DNA sequences can be used to understand the evolutionary forces acting on populations or species, either in general or at specific genes.
What's included
7 videos1 reading2 assignments
Show info about module content
7 videos•Total 88 minutes
Evolutionary Advantages of Sex (G)•11 minutes
Recombination, Selective Sweeps, and Hitchhiking (S)•15 minutes
Signatures of Natural Selection (S)•9 minutes
Background Selection (S)•8 minutes
Signatures of Natural Selection in Individual Genes (G,S)•16 minutes
Searching for Natural Selection: dN/dS (S)•14 minutes
Searching for Natural Selection: McDonald-Kreitman Test (S)•15 minutes
This module changes gears a bit to look at the exciting field of animal behavior-- specifically, how particular behaviors are or may be adaptive, and why individuals choose particular others as mates.
What's included
5 videos1 reading2 assignments
Show info about module content
5 videos•Total 75 minutes
Optimality and Adaptive Feeding (G)•19 minutes
Communication and Parental Care (G)•18 minutes
Intro to Sexual Selection (G)•14 minutes
Sexual Selection: Male Competition and Female Choice (G)•14 minutes
Sexual Selection: Evolutionary Causes (S)•10 minutes
1 reading•Total 10 minutes
Supplemental Materials, Adaptive Behaviors and Sexual Selection•10 minutes
2 assignments•Total 60 minutes
Adaptive Behaviors and Sexual Selection Quiz•30 minutes
Behavior and Sexual Selection Problem Set•30 minutes
Speciation and Phylogenetics
Module 11•3 hours to complete
Module details
This module gets into the nitty gritty of what causes the formation of new species, and how evolutionary relationships between species are inferred.
What's included
6 videos1 reading2 assignments
Show info about module content
6 videos•Total 92 minutes
Keeping Species Separated (G)•19 minutes
Speciation: Effects of Geography (S)•15 minutes
Speciation: Genetic Control (S)•14 minutes
Reading Evolutionary Trees (G)•19 minutes
Generating Evolutionary Trees (S)•18 minutes
Phylogenetic Comparative Method (S)•8 minutes
1 reading•Total 10 minutes
Supplemental Materials, Speciation and Phylogenetics•10 minutes
2 assignments•Total 60 minutes
Speciation and Phylogenetics Quiz•30 minutes
Speciation and Phylogenetics Problem Set•30 minutes
Applied Evolution
Module 12•1 hour to complete
Module details
This final module talks about applications and misapplications of many of the concepts discussed in the course to human health, understanding, and well-being. This module is optional and not included in the assessments.
What's included
2 videos2 readings
Show info about module content
2 videos•Total 27 minutes
Applications of Evolutionary Insights (G)•17 minutes
MISapplications of Evolutionary Insights (G)•10 minutes
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Showing 3 of 1897
M
MH
5·
Reviewed on Sep 20, 2020
A wide-ranging introduction that will make you want to read and learn more. The assessments are doable but challenging. The instructor is a widely-published expert in the field and a delight.
T
TN
5·
Reviewed on Sep 27, 2017
Very good course that prepared me for Genetics at Pima Community College in Tucson. I am able to follow the lectures and actually understand what is being presented. I am glad I took this course.
M
MB
5·
Reviewed on Mar 28, 2019
Very thorough introduction to the subject. As someone who comes from a math background, the biological terms and theory were explained very well. Dr. Noor was an excellent teacher.
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