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Genomic and Precision Medicine

A critical, unbiased introduction to using new genomic tools for diagnosing and managing disease.


Course at a Glance

About the Course

*** NOTE: The course videos can be accessed on-demand here. For questions, please contact me at

Precision medicine has the potential to change fundamentally how health care is practiced, but requires a health care workforce that understands the complexities of this field. One important component of Precision Medicine is the use of an individual’s genomic information to offer targeted treatment, tailored to the individual. Our course aims to provide participants with some baseline knowledge of genomics, an overview of the clinical applications of genomic medicine, the skills to evaluate the clinical validity and utility of new tests, and an appreciation of the associated ethical and social issues inherent in this field. 

The course is geared toward practicing health care providers, although it should be accessible to anyone with a background in the biological sciences and a basic understanding of genetics.  It is designed to be succinct and clinically-focused, offering both conceptual and practical information about real-world applications of genomics. Lessons 1 and 4 offer a basic primer on molecular genomics relevant to the individual patient as well as to patient populations. The remaining five lessons focus on five applications of genomics and present the material as case studies, highlighting the strengths, limitations, and issues that arise in the use of each test.

Course Syllabus

Week 1: New insights into the structure of the human genome and different types of genetic and non-genetic variation that occur

Week 2: Genetic screening and diagnosis: prenatal carrier testing and newborn screening for Mendelian diseases

Week 3: The use of next-generation sequencing for solving diagnostic dilemmas

Week 4: Methods used in patient populations to uncover associations between genome variation and common diseases

Week 5: Predictive tests for common, complex diseases

Week 6: Pharmacogenomic testing for drug selection, dosing and predicting adverse effects of commonly prescribed drugs

Week 7: Tumor profiling for targeting cancer treatment and the use of blood-based gene expression profiles in cancer prognosis

Recommended Background

Students should have some background in biology/medicine, and have a basic understanding of genetics.

Suggested Readings

Look for our new textbook, Precision Medicine: A Guide to Genomics in Clinical Practice, published by McGraw Hill in December 2016.

If you are a bit rusty in genetics, we recommend that you check out The New Genetics.  The New Genetics "is a science education booklet [that] explains the role of genes in health and disease, the basics of DNA and its molecular cousin RNA, and new directions in genetic research."  The publication can be accessed at the following link:

National Institute of General Medical Sciences.  (2010).  The New Genetics.  Bethesda, MD: U.S. Department of Health and Human Services.

Course Format

Each week will consist of approximately two hours of work for students to complete: 60 minutes of video lectures and 30-60 minutes to complete homework/assessments.



  • Will I get a Statement of Accomplishment after completing this class?

Yes. Students who successfully complete the class will have the opportunity to receive a Statement of Accomplishment signed by the instructor.

  • Is this class eligible for Signature Track?

Yes. Prior to the beginning of the class, and during the first two weeks, students may sign up for Signature Track to earn a Verified Certificate. Details on Signature Track are available from Coursera in their Signature Track Guidebook.

  • Will Continuing Education credit for practicing physicians be available for this class?

14.00 AMA PRA Category 1 Continuing Medical Education (CME) credits are available for practicing physicians and other health professionals who complete this course with a final grade of 70% or above. Please check the course site for detailed information on registration policies, prices, and deadlines.