Health care professionals increasingly have to make clinical decisions in aging and diverse populations. Also, they have to deal with rising health care costs, fragmented health care supply and advancing medical technologies and IT systems. These developments go beyond every day practice and will require new skills. In this course we will walk you through key steps in designing a research study, from formulating the research question to common pitfalls you might encounter when interpreting your results. We will focus primarily on analytical studies used in etiological research, which aims to investigate the causal relationship between putative risk factors (or determinants) and a given disease or other outcome. However, the principles we will discuss hold true for most research questions, and you will also encounter these study designs in prognostic and diagnostic research settings.
This course is part of a Master's program Population Health Management at Leiden University (currently in development), which includes nine courses on Coursera (including this one). If you are interested in learning more about the Population Health Management approach follow the course "Population Health: Fundamentals of Population Health Management" on Coursera.
Welcome to Population Health: Study Design! In this module you will get to know what the scope is of this course and you will learn how to be successful at online studying.
What's included
2 videos3 readings1 discussion prompt1 plugin
Show info about module content
2 videos•Total 4 minutes
Population Health: Study Design•2 minutes
How to succeed in your online class?•2 minutes
3 readings•Total 30 minutes
Meet the instructors•10 minutes
About this course•10 minutes
Glossary•10 minutes
1 discussion prompt•Total 10 minutes
Introduce yourself•10 minutes
1 plugin•Total 2 minutes
Discover The World at Leiden University [video]•2 minutes
Design
Module 2•9 hours to complete
Module details
In this module you will start to formulate a research question. You will be introduced to the most important study designs in epidemiology, and work out which study design fits your specific research question.
Experimental versus observational studies•9 minutes
The cohort study•7 minutes
The case-control study•9 minutes
Bloodcurdling movies and measures of coagulation - a crossover trial•7 minutes
To conclude•1 minute
2 readings•Total 120 minutes
Observational research methods: cohort, cross sectional, and case-control studies•60 minutes
Designing a research project: randomised controlled trials and their principles.•60 minutes
4 assignments•Total 210 minutes
Observational research methods: cohort, cross-sectional, and case-control studies•10 minutes
Designing a research project: randomised controlled trials and their principles.•10 minutes
Reflect on your goals•10 minutes
Test your knowledge•180 minutes
4 discussion prompts•Total 120 minutes
How does epidemiology link to population health?•15 minutes
What is the research question?•15 minutes
Formulate three research questions•45 minutes
Which study design fits your research question?•45 minutes
1 plugin•Total 20 minutes
Balance through randomisation•20 minutes
Measures
Module 3•6 hours to complete
Module details
In this module you will calculate frequency and effect measures, and apply them to your own research questions. In addition, you will practice with constructing a life table and drawing a Kaplan-Meier curve.
Thoughts on absolute versus relative risk•8 minutes
To conclude•1 minute
2 readings•Total 180 minutes
R tutorial•120 minutes
Time partition•60 minutes
4 assignments•Total 55 minutes
Calculate frequency and effect measures•20 minutes
Exposure window•5 minutes
Reflect on your goals•10 minutes
Test your knowledge•20 minutes
1 discussion prompt•Total 30 minutes
Frequency and effect measures in your study design•30 minutes
1 plugin•Total 45 minutes
Life table and Kaplan-Meier•45 minutes
Confounding and bias
Module 4•7 hours to complete
Module details
In this module different types of error will be discussed, which can be either random or systematic in nature. Subsequently, you will learn to recognize bias and confounding. You will additionally gain hands-on experience with standardisation.
Recognising potential biases and confounders•90 minutes
Study design - what can go wrong?•90 minutes
1 plugin•Total 45 minutes
Balance through randomisation•45 minutes
Inference
Module 5•8 hours to complete
Module details
In this module you will calculate with averages, learn basic principles of causal inference, and be introduced to the concepts of regression to the mean and intention to treat.
Leiden University is one of Europe's foremost research universities. This prominent position gives our graduates a leading edge and prepares them for careers both within and outside of academia. Leiden University is the oldest university in the Netherlands, founded in 1575. Our motto is: Praesidium Libertatis (Bastion of Liberty) - Freedom of spirit, thought and expression. Leiden University has a campus in Leiden and The Hague, with 7 faculties, 47 Bachelor Programmes, 79 Master Programmes and nearly 30,000 students.
When will I have access to the lectures and assignments?
To access the course materials, assignments and to earn a Certificate, you will need to purchase the Certificate experience when you enroll in a course. You can try a Free Trial instead, or apply for Financial Aid. The course may offer 'Full Course, No Certificate' instead. This option lets you see all course materials, submit required assessments, and get a final grade. This also means that you will not be able to purchase a Certificate experience.
What will I get if I purchase the Certificate?
When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile.
Is financial aid available?
Yes. In select learning programs, you can apply for financial aid or a scholarship if you can’t afford the enrollment fee. If fin aid or scholarship is available for your learning program selection, you’ll find a link to apply on the description page.