About this Course
4.8
187 ratings
43 reviews
Kidney transplantation is a major advance of modern medicine which provides high-quality of life for patients with end-stage renal disease. What used to be an experimental, risky, and very limited treatment option more than 50 years ago is now routinely performed in many countries worldwide. The number of renal transplants is expected to rise sharply in the next decade since the proportion of patients with end stage renal disease is increasing. Are you interested in clinical kidney, pancreas and islet transplantation? If you are a (bio) medical student or a health care professional who works in the (pre) clinical transplant field this might be the course for you. This course is also for anyone interested in the research and knowledge on clinical transplantation. The course will be taught by a multidisciplinary team of transplant professionals and will give you the state of the art updates. It is divided in 4 modules: 1) Before the transplant 2) The surgical procedures and the challenged patient, including the patient with diabetes 3) Early challenges 4) Late challenges after transplantation. The offered modules will include lectures, interactive patient cases, 3D movies, interviews with well-known experts and with patients and a donor, a serious game to increase knowledge of the field and of course an active forum. Become an expert and join us! The course is endorsed by The European Society of Organ Transplantation (ESOT), The International Society of Nephrology (ISN) and The Transplantation Society (TTS). This MOOC has been accredited for Continuing Medical Education (CME). Health care professionals who works in the (pre) clinical transplant field, other health care professionals and general practitioners can obtain CME credit at 'LUMC-Boerhaave CME' upon passing the course. For more information we like to refer to the "Additional introduction for obtaining CME credit" module in week 1 of the course For another interesting course on organ donation and transplantation, see Organ Donation: From Death to Life from Cape Town University https://www.coursera.org/learn/organ-donation...
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Intermediate Level

Intermediate Level

Clock

Suggested: 4 weeks of study, 4-6 hours a week

Approx. 15 hours to complete
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English

Subtitles: English
Globe

100% online courses

Start instantly and learn at your own schedule.
Calendar

Flexible deadlines

Reset deadlines in accordance to your schedule.
Intermediate Level

Intermediate Level

Clock

Suggested: 4 weeks of study, 4-6 hours a week

Approx. 15 hours to complete
Comment Dots

English

Subtitles: English

Syllabus - What you will learn from this course

1

Section
Clock
1 hour to complete

Welcome to the course

Great that you are joining us! In this course you will learn about clinical kidney, pancreas and islet transplantation and its challenges. Before you start with studying we invite you first go through our introduction module and introduce yourself in the forum to meet your fellow learners. Medical professionals can receive Continuing Medical Education (CME) credit for this course. Information on CME credit and how to obtain credit can be found in our CME credit module. If you encounter any difficulties while studying, please let us know in the forum. For technical difficulties or questions regarding the course certificate, you can always contact the Coursera Learner Helpdesk. Good luck & we hope you enjoy studying in this course!...
Reading
1 video (Total 2 min), 9 readings
Reading9 readings
About us: Introduction to the Team5m
Welcome to Leiden University5m
Complete our short survey10m
Tips for studying online5m
Being successful in an international virtual learning environment5m
Behaving in an academic way5m
CME information10m
How to apply for CME credit10m
CME FAQs10m
Clock
5 hours to complete

Before the Transplant

Welcome to this first module of the course! We will answer important questions before transplantation. These include: why is transplantation the preferred option for patients with end stage renal disease? What are the immunological barriers for transplantation? And what are the selection criteria before transplantation? Unique 3D movies about the different immunological tests will help you to understand the concepts. There are also optional lectures, including a fascinating movie about the Eurotransplant allocation system and patient/donor interviews. At the end of the module we will link the contents you have learned to clinical patient cases, patient - donor interviews and a quiz. You can find each other on the discussion forum. With the e-tivities you can apply your knowledge. In the honors lessons more in depth immunological testing and pre transplant screening can be obtained. The lesson also includes peer reviews about important preclinical questions. Have fun and good luck with the first module!...
Reading
11 videos (Total 79 min), 4 readings, 3 quizzes
Video11 videos
The Kidney in Health and Disease5m
Options if Kidneys Fail5m
Immunogenetics7m
Introduction to the Immune System6m
The Humoral Immune System6m
Histocompatibility7m
Cases from Daily Practice - Patient Selection7m
Eurotransplant Company Film 'More than a Match'13m
Interview: Transplant Recipient and Donor: Part 110m
Epitopes6m
Reading4 readings
Glossary10m
References5m
HLA Epitope Matching is the Future30m
HLA Antibody Detection: Not All Antibodies are the Same30m
Quiz2 practice exercises
Check your knowledge30m
Check your knowledge10m

2

Section
Clock
8 hours to complete

The Procedure and the Patient

Now you know the factors of importance before transplantation, including the immunological barriers and important aspects for patient selection, we can focus on challenged patient groups and on surgical procedures. What does a kidney, pancreas and islet transplantation surgical procedure look like? What is important? And what are the key aspects in elderly patients, patients with diabetes and immunological challenged patients. We have unique visulisations, 360 virtual reality videos and a game about a patient case. Advanced readings will invite you to look at the different subjects in more depth. At the end of the module there are interviews about a patient with diabetes and the transplant recipient and donor to illustrate the impact of life. You can discuss patient cases on the forum together with your peers. In the honors lesson you can apply knowledge about more in depth immunological, surgical and metabolic challenges and living kidney donation. Let’s start and we hope you will enjoy this module....
Reading
14 videos (Total 111 min), 7 readings, 3 quizzes
Video14 videos
Immunological Challenged Patient: ABO Incompatible Transplants6m
Immunological Challenged Patient: Highly Sensitized Patient6m
The Diabetic Patient10m
The Elderly Patient6m
Organ Procurement and Preservation9m
Kidney Transplant Surgery7m
Simultaneous Pancreas Kidney & Islet Transplantation15m
A: Cases from Daily Practice: Different Choices for Different Diabetic Patients5m
B: Cases from Daily Practice: Different Choices for Different Diabetic Patients6m
Interview: Patient with Diabetes14m
Interview: Transplant Recipient and Donor: Part 24m
B Cell Replacement and Diabetes Type II11m
Surgical Challenged Patients6m
Reading7 readings
Introduction to Watching 360 VR Videos10m
Serious Game: A Patient with Immunological Challenges30m
Glossary10m
References5m
Highly Sensitized Patients: The AM Program30m
Additional Challenged Transplant Recipients30m
Living Kidney Donation30m
Quiz2 practice exercises
Check your knowledge30m
Check your knowledge20m

3

Section
Clock
10 hours to complete

Early Challenges in Transplantation

You are now familiar with the basic knowledge about challenges in transplant recipients and the surgical transplant procedures. Once the transplantation has been successful, it doesn’t mean everything is stable. What are actually the graft survival data? Which challenges do we face in the first months? How can we tackle these challenges? 3D movies about early surgical challenges and about the targets for immunosuppressives, including cell therapy, will help you to understand the concepts. In addition, we invite you to master the advanced knowledge and to give your opinion in the patient cases in the forum. There is also a serious game about a patient case. Can you solve the challenges? And can you think of a scenario for the game and help us with building? We will make a game of the best scenario, which will be incorporated in the course. In the honors lesson you can learn in more detail about immunological concepts, including the complement system. A patient case will help to show you the importance of this knowledge. Good luck with this module and happy learning!...
Reading
12 videos (Total 95 min), 9 readings, 3 quizzes
Video12 videos
Surgical Challenges in the Early Period5m
Ischemia Reperfusion Injury6m
Cellular Rejection8m
Antibody Mediated Rejection6m
Immune Suppression10m
Novel Therapeutics: Cell Therapy after Transplantation8m
Cases from Daily Practice A - Patient Cases with Early Challenges6m
Cases from Daily Practice B - Patient Cases with Early Challenges6m
Interview Transplant Recipient & Donor: Part 38m
The Complement System and Transplantation11m
Cases from Daily Practice: Patient Case with an Early Challenge7m
Reading9 readings
Serious Game: Interactive Patient Case30m
Optional - Immunesuppressive Regimens and Toxicity Profilesm
Biomarkers40m
Therapeutic drug monitoring of immunosuppressive drugsm
Glossary10m
References5m
A closer Look at Antibody Mediated Rejection30m
Innate Immunity and Impact on Transplantation30m
Molecular Insights into Cellular Rejection30m
Quiz2 practice exercises
Check your knowledge20m
Check your knowledge10m

4

Section
Clock
7 hours to complete

Late Challenges in Transplantation

Now you’ve learned about the challenges in the early period after transplantation. But what about the late period? What is the long term patient and allograft survival? Have we improved in the last decades? What are the main causes for morbidity and mortality? And can we reach tolerance in the future? We invite you to give your opinion in the patient cases and to discuss it on the forum. There are also advanced readings to look at additional subjects, including recurrence of the kidney disease after transplantation, the organization of dermatological care for the transplant recipient and the role of the patient himself in the whole process. The interview about tolerance gives you insight why pregnancy is of interest to understand the concept of tolerance and which steps have been made from lab research to a clinical protocol. In the honors lesson late challenges will be discussed in more detail, with a focus on infections, recurrence of the kidney disease after transplantation and tolerance. Have fun and good luck with this last module....
Reading
12 videos (Total 96 min), 5 readings, 6 quizzes
Video12 videos
Infections: Overview and CMV infection8m
Infections: BK and EBV infection7m
Malignancies8m
Late Challenges after Pancreas and Islet Transplantation8m
Post Transplant Diabetes Mellitus8m
Cardiovascular Disease7m
Tolerance: Interview with Prof. Claas (LUMC) and Prof. Wood (Oxford)13m
Cases from Daily Practice A - Patient Cases with Late Challenges5m
Cases from Daily Practice B - Patient Cases with Late Challenges6m
Recurrence of Kidney Disease after Transplantation8m
Vaccination and Transplantation8m
Reading5 readings
Pneumocystis jirovecii10m
Glossary10m
References5m
Skin Diseases after Transplantation and Dermatological Aftercare30m
Tolerance in more Detail30m
Quiz5 practice exercises
Check your knowledge30m
Patient Case 1: Enhanced Glucose after SPK15m
Patient Case 2: Hyperglycemia after Islet Transplantation15m
Patient Case 3: A Complication after Pancreas-alone Transplantation15m
Check your knowledge20m
Clock
1 hour to complete

Final Quiz

We hope you have enjoyed all the modules. Good luck with the final quiz! If you are interested in an intensive course about transplantation go to the course resources....
Reading
1 reading, 2 quizzes
Reading1 reading
Complete our short survey10m
Quiz2 practice exercises
Final Examm
Final Honours Exam16m
4.8
Briefcase

83%

got a tangible career benefit from this course
Money

11%

got a pay increase or promotion

Top Reviews

By SWDec 27th 2016

Wonderful course. Great instruction on very interesting topics. Videos support learning and a good amount of information every week. Thanks for the organization and delivery of this course.

By AEMay 24th 2017

THE BEST COURSE I have taken in COURSERA\n\nGREAT LECTURERS , BEST VIDEOS, AND VERY ORGANIZED\n\n3D movies are really fantastic\n\nHope to join in future sessions to get better scores

Instructors

Marlies Reinders

Dr.
LUMC, Department of Nephrology and Transplantation

Frans Claas

Professor
LUMC, Department of Immunohaematology and Blood Transfusion

Cees van Kooten

Professor
LUMC, Department of Nephrology and Transplantation

Sebastiaan Heidt

Dr.
LUMC, Department of Immunohaematology and Blood Transfusion

Volkert Huurman

Dr.
LUMC, Department of Transplant Surgery

Hans de Fijter

Professor
LUMC, Department of Nephrology and Transplantation

Eelco de Koning

Professor
LUMC, Department of Nephrology and Transplantation and Endocrinology and Metabolism

Andre Baranski

Dr.
LUMC, Department of Transplant Surgery

Ton Rabelink

Professor
LUMC, Department of Nephrology and Transplantation

Aiko de Vries

Dr.
LUMC, Department of Nephrology and Transplantation

Jan Nico Bouwes Bavinck

Dr.
LUMC, Department of Dermatology

Leo Visser

Professor
LUMC, Department of Infectious Diseases

Ingeborg Bajema

Dr.
LUMC, Department of Pathology

About Universiteit Leiden

Leiden University is one of Europe's foremost research universities. This prominent position gives our graduates a leading edge in applying for academic posts and for functions outside academia. Leiden University is the oldest university in the Netherlands. It was founded in February 1575, as a gift from William of Orange to the citizens of Leiden after they had withstood a long siege by the Spanish. Our motto is: Praesidium Libertatis — Bastion of Liberty....

About Leiden University Medical Center

Frequently Asked Questions

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

  • Continuing Medical Education (CME) consists of educational activities that aim to maintain, develop, or increase the knowledge, skills, and professional performance in order to maintain competence and learn about new and developing areas of the medical field. Content for these programs is developed, reviewed, and delivered by faculty who are experts in their individual clinical areas. In various countries, a certain amount of CME-credit hours must be obtained by medical professionals to maintain their licenses.

    For this course it is possible to obtain 5, 9 or 13 CME credit points. For more information on how to obtain these points we like to refer to the "Additional introduction for obtaining CME credit" module in week 1 of the course

  • Yes, if you have already done the course previously and obtained the Coursera official Course Certificate as proof we encourage you to apply for the CME credits. You can obtain 5 or 9 CME as follows:

    1. Sign up for the course at “Boerhaave Continuous Medical Education” (https://www.boerhaavecontinuousmedicaleducation.com/)

    2. Upload your Verified Certificate from Coursera (without honors 5 CME or with honors 9 CME). Pay the contribution according to “Boerhaave Continuous Medical Education." They will provide you with the instructions and add the CME credits to GAIA (Dutch participants) and/or provide you with a CME certificate (international participants)

More questions? Visit the Learner Help Center.