This introductory virology course explores the interplay between viruses and their host organisms. The course begins with an overview of how infection is established in a host, then moves to a virologist's view of immune defenses. Next we consider how the replication strategy and the host response determine the outcome of infection, such that some are short and others are of long duration. The mechanisms by which virus infections transform cells in culture are explored, a process that may lead to tumor formation in animals. We then move to a discussion of how viral infections are controlled by vaccines and antiviral drugs. After an introduction to viral evolution, we discuss the principles learned from zoonotic infections, emerging infections, and humankind's experiences with epidemic and pandemic viral infections. The course ends with an exploration of unusual infectious agents such as viroids, satellites, and prions, followed by a discussion of the causative agent of the most serious current worldwide epidemic, HIV-1.
Two semesters of a rigorous, molecularly-oriented introductory biology course and Virology I: How Viruses Work.
The recommended textbook is Principles of Virology. Vol I: Molecular Biology, Vol. II: Pathogenesis and Control (S.J. Flint et al., Third Edition, ASM Press 2009). You don't need to buy this book to do well in this course, as the lectures are self-contained, but if you are very interested in virology, it's a great resource.
This class consists of lecture videos which are between 10-15 minutes in length. There will also be standalone quizzes and a final exam.
Yes. Students who successfully complete the class will receive a Statement of Accomplishment.
For this course, you need an Internet connection and the time to read, write, discuss, and enjoy the various resources on virology.